دوره 14، شماره 1 - ( 12-1403 )
جلد 14 شماره 1 صفحات 0-0 |
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Roshandel A, Vithanala S R, Kandula S K, Roshandel F. Analysis Of Antidepressants with And Without Anticholinergic Properties on Cognitive Function in Patients with Heart Failure. J Emerg Health Care 2025; 14 (1)
URL: http://intjmi.com/article-1-1305-fa.html
URL: http://intjmi.com/article-1-1305-fa.html
Analysis Of Antidepressants with And Without Anticholinergic Properties on Cognitive Function in Patients with Heart Failure. . 1403; 14 (1)
چکیده: (42 مشاهده)
Objective: This paper conducts a systematic review and meta-analysis with the aim of integrating findings, discovering clinical insights and understanding the effect of different depression treatments on cardiovascular health in different groups of patients. The main objective is to analyze antidepressant drugs with and without anticholinergic properties on cognitive function in patients with heart failure.
Material and Methods: A systematic review and meta-analysis were performed on 14 studies investigating the effects of depression treatments on cardiovascular outcomes, including mortality, readmissions, and emergency department (ED) visits.
Results: The findings were revealed antidepressants were effective in alleviating depressive symptoms; they were linked to a higher risk of adverse outcomes in certain subgroups, such as older adults and those without clinical depression. Subgroup analysis indicated that depression treatments were more effective in heart failure (HF) patients than in coronary artery disease (CAD) patients, as evidenced by a significantly lower effect size in the HF group. The obtained results indicate the need for cautious use of pharmacotherapy, particularly in older adults and patients with multiple comorbidities, due to the potential for adverse outcomes. The findings revealed that while therapeutic methods can be effective, their effects vary depending on the patient's properties, the type of cardiovascular disease, and specific therapies.
Conclusion: It can be concluded that psychotherapy appears as a more effective and safer option for many patients, especially heart failure and younger patients, because of its protective effect on cardiovascular consequences as well as the lack of side effects related to the drug. These results suggest that clinicians should tailor depression treatment strategies based on the patient characteristics, cardiovascular health, and individual risk factors.
Material and Methods: A systematic review and meta-analysis were performed on 14 studies investigating the effects of depression treatments on cardiovascular outcomes, including mortality, readmissions, and emergency department (ED) visits.
Results: The findings were revealed antidepressants were effective in alleviating depressive symptoms; they were linked to a higher risk of adverse outcomes in certain subgroups, such as older adults and those without clinical depression. Subgroup analysis indicated that depression treatments were more effective in heart failure (HF) patients than in coronary artery disease (CAD) patients, as evidenced by a significantly lower effect size in the HF group. The obtained results indicate the need for cautious use of pharmacotherapy, particularly in older adults and patients with multiple comorbidities, due to the potential for adverse outcomes. The findings revealed that while therapeutic methods can be effective, their effects vary depending on the patient's properties, the type of cardiovascular disease, and specific therapies.
Conclusion: It can be concluded that psychotherapy appears as a more effective and safer option for many patients, especially heart failure and younger patients, because of its protective effect on cardiovascular consequences as well as the lack of side effects related to the drug. These results suggest that clinicians should tailor depression treatment strategies based on the patient characteristics, cardiovascular health, and individual risk factors.
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