دوره 15، شماره 1 - ( 11-1404 ) جلد 15 شماره 1 صفحات 0-0 | برگشت به فهرست نسخه ها

Behvandi S, Mohammadi M, Mohammadian B. The Beneficial Effects Of Garlic And Mountain Tea Hydroalcoholic Extract On Methotrexate-Induced Liver Toxicity Through Attenuation Oxidative Stress. J Emerg Health Care 2026; 15 (1)
URL: http://intjmi.com/article-1-1367-fa.html

The Beneficial Effects Of Garlic And Mountain Tea Hydroalcoholic Extract On Methotrexate-Induced Liver Toxicity Through Attenuation Oxidative Stress. . 1404; 15 (1)

URL: http://intjmi.com/article-1-1367-fa.html

The Beneficial Effects Of Garlic And Mountain Tea Hydroalcoholic Extract On Methotrexate-Induced Liver Toxicity Through Attenuation Oxidative Stress

چکیده: (37 مشاهده)

Background: Methotrexate (MTX), a chemotherapeutic and immunosuppressant drug, is generally well-tolerated by most patients. However, its cytotoxic nature contributes to life-threatening side effects including hepatotoxicity and nephrotoxicity. Several studies have already confirmed that the oxidative stress plays a major role in the pathogenesis of MTX-induced damage in the various organs. This study was carried out to determine whether garlic extract has a protective effect against MTX-induced hepatotoxicity and nephrotoxicity.
Materials and methods: 56 rats were divided randomly into six groups: Group I (control): treated with normal salin. Group II (MTX): was received sin-dose MTX(20mgkgi.p, 7^th ). The third, fourth and fifth groups of the extract received 100, 250 and 500 mg/kg doses per day, respectively, and on day 7, methotrexate was given intraperitoneally at a dose of 20. Sixth, seventh and eighths of the group received the tea extract from 30, 50 and 70 mg/kg doses per day, respectively, and on day 7 received methotrexate intraperitoneally at a dose of 20 mg/kg. After 11 days, the liver tissue was removed for measure the MDA, TAC, GSH and CAT, SOD activity in tissue homogeneity and histopathologic studies.
Results: The results showed that CAT(P <0.001), TAC(P <0.01) and GSH (P <0.05)levels decreased in methotrexate group compared to control group. These values increased in the third to the eighth groups compared to the methotrexate group. Also, the MDA content in methotrexate group increased compared with the control group(P <0.001), which decreased in the third to eighth groups compared to the methotrexate group. MTX had no significant effect on SOD levels.

Conclusion: Our results demonstrate that the prescription of garlic extract and mountain tea has a protective role against methotrexate's liver toxicity, which can be due to their antioxidant properties.

نوع مطالعه: پژوهشي | موضوع مقاله: عمومى

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