[Home ] [Archive]    
:: Main About journal Editorial Board Current Issue Archive Submit an article Site Map Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 5, Issue 2 (june 2016) ::
Int J Med Invest 2016, 5(2): 69-72 Back to browse issues page
Case report: A 27 years old woman with brain metastases of synovial sarcoma
Anahita Nosrati , Sajad Shafiee * , Emadi Aazam
Department of neurosurgery, Imam Khomeini hospital, Mazandaran university of medical sciences .Sari, Iran.
Abstract:   (9035 Views)

A 27- year old lady with severe headache, nausea, vomiting and impaired cerebellar function. She had a history of a left arm synovial sarcoma and she was evaluated with magnetic resonance imaging (MRI) that shows a gadolinium enhanced mass measuring about 7 mm in diameter with both solid and cystic portions in left cerebellar hemisphere causing mass effect. Histologic evaluation confirmed poorly differentiated type synovial sarcoma composed of tumor cells containing pleomorphic round to oval hyper chromatic to vesicular nuclei with coarse chromatin and a little light eosinophilic cytoplasm. The IHC stain is done and showed EMA, CK and vimentin positivity in tumor cells. The patient was treated with surgery, chemotherapy and radiotherapy. In the follow up study at 6 month post chemotherapy evaluation computed tomography (CT scan) showed pulmonary metastases and transthoracic biopsy revealed the same pathologic feature. According to our patient, brain metastasis could occur even in extremities synovial sarcoma and so CNS imaging as screening may be introduced in follow up plan of these patients.

Keywords: synovial sarcoma, brain metastases, pulmonary metastases.
Full-Text [PDF 454 kb]   (2455 Downloads)    
Type of Study: case report | Subject: General
References
1. 1. Weiss S, Goldblum J, Publishing M. Enzinger and Weiss’s Soft Tissue Tumors. St Louis, MI: Mosby 2001. 2. Milchgrub S, Ghandur-Mnaymneh L, Dorfman HD, Albores-Saavedra J. Synovial sarcoma with extensive osteoid and bone formation. Am J Surg Pathol 1993; 17: 357–363. 3. Miettinen M, Virtanen I. Synovial sarcoma—a misnomer. Am J Pathol 1984; 117: 18–25. 4. Smith ME, Fisher C, Wilkinson LS, Edwards JC. Synovial sarcoma lack synovial differentiation. Histopathology 1995; 26: 279–281. 5. Haldar M, Hancock JD, Coffin CM et al. A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell 2007; 11: 375–388. 6. Lewis JJ, Antonescu CR, Leung DH et al. Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity. J Clin Oncol 2000; 18: 2087–2094. 7. Okcu MF, Munsell M, Treuner J et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J Clin Oncol 2003; 21: 1602–1611. 8. Fletcher CDM, Unni KK, Mertens F. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press 200. 9. 1. Spillane AJ, A’Hern R, Judson IR Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging and prognostic assessment. J Clin Oncol. 2000; 18(22):3794-3803. 10. Sabrazes J, Loubat E, de Grially R, Magendie J. Synovial sarcomas. Gaz Hebd Sc Med Bordeaux. 1934;55:754–62. 11. Rong R, Doxtader EE, Tull J, de la Roza G, Zhang S. Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: A molecular genetic analysis. Int J Clin Exp Pathol. 2010;3:217–21. [PMC free article] [PubMed] 12.Blazer DG III, Sabel MS, Sondak VK. Is there a role for sentinel lymph node biopsy in the management of sarcoma? Surg Onc. 2003; 12(3):201-206. 13.Stojadininovic A, Leung DH, Allen P Allen P, Lewis JJ, Jaques DP, Brennan MF. Primary adult soft tissue sarcoma: time dependent influence of prognostic variables. J Clin Oncol. 2002; 20(21):4344-4352 14.Utsunomiya A, Kinouchi H, Kayama T Yoshimoto T. Distant metastasis of liposarcoma to the dura and skull: a case report. Br J Neurosurg. 1999; 13(5):520-522. 15.Takamiya Y, Toya S, Iizaka Y, Otani M, Takenaka N, Imanishi T. Intracranial metastasis of soft tissue fibrosarcoma- a case report. Neurol Med Chir. 1986; 26(1):54-57. 16.Lefkovitz NW, Roessmann U, Kori SH. Major cerebral infarction from tumor embolus. Stroke. 1986; 17(3):555-557. 17. Otani Y1, Ichikawa T, Kurozumi K, Yanai H, Kunisada T, Ozaki T, Date I. A case of synovial sarcoma with brain metastasis treated with surgical resection and stereotactic radiosurgery. No Shinkei Geka. 2013 Mar;41(3):255-62. 18. Siegel HJ1, Dunahm WH, Lopez-Ben R, Siegal GP. Intracranial metastasis from synovial sarcoma. Orthopedics. 2008 Apr;31(4):405. 19. Paras Nuwal, Ramakant Dixit, Narender Singh Shah, and Anil Samaria. Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review. Lung India. 2012 Oct-Dec; 29(4): 384–387. 20. Herrick J. Siegel, MD; William H. Dunham, MD; Robert Lopez-Ben, MD; Gene P. Siegal, MD, PhD. Intracranial metastasis from synovial sarcoma. Orthopedics. 2008 April; 31(4):
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nosrati A, Shafiee S, Aazam E. Case report: A 27 years old woman with brain metastases of synovial sarcoma. Int J Med Invest 2016; 5 (2) :69-72
URL: http://intjmi.com/article-1-230-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 2 (june 2016) Back to browse issues page
International Journal of Medical Investigation
Persian site map - English site map - Created in 0.04 seconds with 37 queries by YEKTAWEB 4645