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Esophageal melanosis is a benign clinicopathologic diagnosis which it has been said more common in Asian than western population. In this entity melanin deposition in mucosa with an increased melanocytic proliferation can be realized . Its etiology is unknown but it is doubtful to be one of the precursors of esophageal melanoma . We aimed to represent and review histopathologic features of a case of melanosis. A 80 year old woman with long time history of dyspepsia referred to endoscopy department. There was a past history of reflux disease that under histopathologic evaluation and immunohistochemical staining it turned out to be brownish melanocyte proliferation Esophageal melanosis is a rare benign histopathologic lesion and it has been suggested as a melanoma precursor. Thus, making an accurate diagnosis and patient follow up are recommended.

     

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