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Abstract Objective To evaluate the incidence of unexplained pulmonary hypertension (PH) in end- stage renal disease (ESRD) and to evaluate its possible relationship with some clinical and biochemical parameters. Patients and Methods This study was conducted retrospectively at Prince Rashed Hospital (PRH), North of Jordan, on patients undergoing maintenance hemodialysis (HD) during August 2009 to August 2010.Demographic and clinical data were obtained from charts review and Patients themselves. 2Dimensional echocardiography (2DECHO) was performed in all patients. Blood samples were taken for parathormone (PTH) and other biochemical measurements. SPSS package was used for statistical analysis.Statistical significance was considered at p value < 0.05. Results A total of 131 hemodialysis (HD) patients were included in the study, of them 76 (58, 9%) were men. The mean age of the study population was 53.7 + 16.2 yrs. Pulmonary hypertension (pulmonary artery pressure (PAP)=47+3, range 35-79mmHg) was detected in 52 patients (39.6%).The levels of PAP were positively correlated with serum intact parathormone (iPTH) levels, age, duration of HD, mean arterial pressure (MAP), interventricular septal (IVS) thickness, cardiac output(CO), and serum levels of phosphorus , creatinine, whereas the levels of PAP were inversely correlated with the levels of serum calcium and hemoglobin(Hb). Conclusion Pulmonary hypertension is a frequent finding in end stage renal disease and mineral disorders together with secondary hyperparathyroidism (SHPTH), increased cardiac output and anemia may be involved in the pathogenesis of this abnormality. The early detection and treatment of pulmonary hypertension aiming to decrease its serious complications is mandatory.

     

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