TY - JOUR JF - intjmi JO - Int J Med Invest VL - 8 IS - 2 PY - 2019 Y1 - 2019/5/01 TI - Neurological Disorders due to Recurrent Hypoglycemia TT - N2 - The most important material for the brain tissues is glucose .The brain utilizes around (25%) of the body's glucose, and it's metabolism thought to be primarily by astrocytes through non-insulin dependent (GLUT-1) transporter and insulin dependent (GLUT-4) transporter, but the brain contains very limited stores of glycogen, and therefore it can't regulate it's function for long time without glucose. So neuronal damage can lead to multiple neurological manifestations as a result of hypoglycemia acutely; stroke like symptoms, movement disorders (tremor, ataxia, difficulty of walking), seizures, coma and death; chronically and repetitive leads to cognitive impairment. Which means clinical picture appears according to the area of neuronal damage. SP - 120 EP - 125 AU - Oudat, Mazen AU - Al Domour, Aktham AU - Al Shiab, Awni AU - Al Adamat, Mohamad AU - Al Etan, Shahir AU - Al Dwarii, Abed Rahim AD - Neurologist and Internist at Royal Medical Services, King Hussein Hospital, Amman, Jordan. KW - NMDA receptor: N-Methyl-D-Aspartate receptor KW - WM: White Matter KW - ischemia KW - neuronal DNA KW - Hypoxia KW - Basal ganglia KW - cerebral peduncle. UR - http://intjmi.com/article-1-407-en.html ER -