TY - JOUR T1 - Neurological Disorders due to Recurrent Hypoglycemia TT - JF - intjmi JO - intjmi VL - 8 IS - 2 UR - http://intjmi.com/article-1-407-en.html Y1 - 2019 SP - 120 EP - 125 KW - NMDA receptor: N-Methyl-D-Aspartate receptor KW - WM: White Matter KW - ischemia KW - neuronal DNA KW - Hypoxia KW - Basal ganglia KW - cerebral peduncle. N2 - The most important material for the brain tissues is glucose .The brain utilizes around (25%) of the body's glucose, and it's metabolism thought to be primarily by astrocytes through non-insulin dependent (GLUT-1) transporter and insulin dependent (GLUT-4) transporter, but the brain contains very limited stores of glycogen, and therefore it can't regulate it's function for long time without glucose. So neuronal damage can lead to multiple neurological manifestations as a result of hypoglycemia acutely; stroke like symptoms, movement disorders (tremor, ataxia, difficulty of walking), seizures, coma and death; chronically and repetitive leads to cognitive impairment. Which means clinical picture appears according to the area of neuronal damage. M3 ER -