en عمومى General مروری Review <div><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">This narrative review explores the intricate relationship between thyroid disorders, both&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">hyperthyroidism and hypothyroidism, and their impact on bone health and fracture risk.&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Hyperthyroidism, whether overt or subclinical, has been associated with an increased risk of&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">fractures, emphasizing the significance of addressing thyroid dysfunction to prevent fractures.&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Surgical treatment for hyperthyroidism was found to reduce fracture risk in a nationwide follow-&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">up study, while overt hyperthyroidism was linked to heightened bone turnover, diminished bone&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">density, osteoporosis, and an elevated fracture risk. Additionally, hyperthyroidism&#39;s potential to&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">accelerate linear growth and strain on bones further contributes to fracture susceptibility. In</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">older men, lower levels of thyroid-stimulating hormone (TSH) were associated with a higher risk&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">of hip fractures, indicating a specific connection between thyroid function and hip fracture risk.&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Graves&#39; disease, often leading to prolonged untreated hyperthyroidism, can result in bone&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">density loss and an increased risk of osteoporosis. The impact of thyroid hormones and thyroid&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">autoantibodies on bone mineral density in premenopausal women with Graves&#39; disease was&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">also explored, revealing a clinically relevant influence of thyroid function on bone modulation.&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Furthermore, the review discusses the potential protective role of TSH receptor antibodies&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">(TRAb) on bones in patients with Graves&#39; thyrotoxicosis and Graves&#39; orbitopathy. The review&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">concludes by highlighting the importance of monitoring bone health in thyroid disease patients&nbsp;</span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">and the need for further research to fully understand these complex interactions.</span></span></span><br> &nbsp;</div> Hyperthyroidism, Thyroid cancers, Osteoprosis 51 57 http://intjmi.com/browse.php?a_code=A-10-1-565&slc_lang=en&sid=1 Solmaz Askari 10031947532846006788 10031947532846006788 Yes Assistant Professor Of Internal Medicine, Department Of Internal Medicine, Faculty Of Medicine, Golestan University Of Medical Sciences, Gorgan, Iran. Marzieh Porgholi 10031947532846006789 10031947532846006789 No Assistant Professor Of Internal Medicine, Department Of Internal Medicine, Faculty Of Medicine, Mazandaran University Of Medical Sciences, Ramsar, Iran