en عمومى General پژوهشي Research <span style="font-size:14pt"><span style="unicode-bidi:embed"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496"><b><span style="font-size:12.0pt"><span style="line-height:150%">Background:</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"> Hemoglobinopathies, the most prevalent single-gene disorders worldwide, are projected to see an increase in prevalence in the future. This study aims to identify abnormal hemoglobin variants in the &Ccedil;ukurova region. </span></span></span></span></span></span></span><br> <span style="font-size:14pt"><span style="unicode-bidi:embed"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496"><b><span style="font-size:12.0pt"><span style="line-height:150%">Methods:</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"> Blood samples were collected at the Central Laboratory of &Ccedil;ukurova University Balcalı Hospital, and abnormal hemoglobin types were determined using hemoglobin electrophoresis, sickling, and ARMS methods. </span></span></span></span></span></span></span><br> <span style="font-size:14pt"><span style="unicode-bidi:embed"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496"><b><span style="font-size:12.0pt"><span style="line-height:150%">Results:</span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"> The study identified 115 cases of HbAS, 60 cases of HbSS, 3 cases of HbSC, 2 cases of HbAC, and 1 case of HbAE. The findings indicate that the carriage of sickle cell traits is highest in the &Ccedil;ukurova region. The objective is to reduce the number of affected births and mitigate the economic burden on the country by implementing screening programs in regions where hemoglobinopathy is endemic.</span></span></span></span></span></span></span><br> <span style="font-size:14pt"><span style="unicode-bidi:embed"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496"><b><span style="font-size:12.0pt"><span style="line-height:150%">Conclusion: </span></span></b><span style="font-size:12.0pt"><span style="line-height:150%">The &Ccedil;ukurova Region&#39;s high prevalence of HbS and the common practice of consanguineous marriages increase the likelihood of babies being born with HbSS. New screening methods are urgently needed to accurately distinguish carriers from patients and rule out common conditions like iron deficiency anemia. The success of screening programs depends on the population&#39;s acceptance, which can be improved through awareness creation and effective genetic counseling post-diagnosis.</span></span></span></span></span></span></span><br> &nbsp; Hemoglobin Variants, Çukurova, Prevalence, Clinical Implications 162 176 http://intjmi.com/browse.php?a_code=A-10-1-594&slc_lang=en&sid=1 Seyyedeh Touran Hosseini 10031947532846006749 10031947532846006749 No Department of Biotechnology, Institute of National and Applied Sciences, Cukurova University, Adana, Turkey Mehmet Akif Çürük 10031947532846006750 10031947532846006750 No Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey Sule Menziletoglu Yildiz 10031947532846006751 10031947532846006751 Yes Balcalı Hospital Blood Center, University of Çukurova, Adana, Turkey.