en عمومى General مروری Review <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b>Background: </b>The human oral microbiome plays a crucial role in maintaining oral health, and disruptions in its equilibrium can lead to dysbiosis, contributing to various oral diseases, including peri-implantitis in dental implant patients. This study aims to explore the functionality and dysbiosis dynamics of the oral microbiome in dental implant outcomes to elucidate the microbial factors influencing peri-implant health and disease progression.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b>Methods:</b> A meta-analytical approach was employed to investigate the functional aspects of microbiome and dysbiosis alterations concerning dental implant outcomes. A comprehensive literature search was conducted to identify relevant studies. Inclusion criteria were applied to select studies focusing on the relationship between the oral microbiome, dysbiosis, and dental implant outcomes. Data extraction was performed to collect relevant information from the selected studies. Statistical analysis, including effect size calculation and heterogeneity assessment, was conducted to synthesize the findings across studies. Sensitivity analysis and assessment of publication bias were performed to ensure the robustness of the results.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b>Results:</b> Eight studies were analyzed, including 217 subjects in the Experimental group and 201 in the Control group. Using a random effects model with the Mantel-Haenszel method, a significant difference was found between the two groups, with an overall risk ratio of 2.26 and a 95% confidence interval of 1.13 to 4.5.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> Significant heterogeneity was observed, indicating that the effects varied widely in magnitude and direction across studies. The I&sup2; value showed that 95% of the variability among studies was due to heterogeneity rather than random chance.</span></span></span><br> &nbsp; Oral Microbiome, Dental Implants, Peri-Implantitis, Dysbiosis Dynamics 9 23 http://intjmi.com/browse.php?a_code=A-10-1-595&slc_lang=en&sid=1 Amin Rashidnezhad 10031947532846006686 10031947532846006686 No Department of Stomatology School of Health Sciences, university of Georgia, Tbilisi, Georgia Golnaz Kazemiyeh 10031947532846006687 0009-0005-2171-7814 No Department of Stomatology School of Health Sciences, university of Georgia, Tbilisi, Georgia Amin Daemi 10031947532846006688 10031947532846006688 Yes Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey