International Journal of Medical Investigation
Int J Med Invest
Medical Sciences
http://intjmi.com
1
admin
2322-2913
2345-640x
no
no
14
8888
13
en
jalali
1394
12
1
gregorian
2016
3
1
5
1
online
1
fulltext
en
The role of opioids, serotonergic and cholinergic pain receptors to induce analgesic effect of Trachyspermum ammi essence using formalin test in mice.
عمومى
General
پژوهشي
Research
<p style="text-align: left">Abstract<br>
Objective: In previous studies it has been demonstrated that different substances, can inhibit pain occurred through opioids, serotonergic, and cholinergic pain receptors these receptors can be inhibited while in presence of naloxone, ondansetron and atropine. Therefore the aim of this study was to determine the effect of Trachyspermum ammi essence on modulation of pain score by the use of formalin test in mice.<br>
Methods: In this experimental study, 20 male mice (20-25) were included. They were randomly divided into test and control groups. The test groups were intraperitoneal injected specific amount of inhibitors such as naloxone, ondansetron and atropine. After 10 min these specimens were injected Trachyspermum ammi essence and were observed for 60 min.to score pain effect caused by formalin injection.<br>
Results: Our result indicated that mean score of the pain during the observation for 60 min (every 5 minutes) of formalin test in groups that received ondansetron, naloxone and TAE it is significantly decrease the pain score whiles group of atropine which induced before TAE significantly (P<0.05) increased the pain score.<br>
Conclusion: In conclusion, this research demonstrated the possible role of cholinergic signaling in antinociceptive effect. Thus more studies are required to prove the further effects of this essence on different signaling systems</p>
Trachyspermum ammi Essense, cholinergic receptor,serotonergic receptor, formalin test,pain.
5
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http://intjmi.com/browse.php?a_code=A-10-1-131&slc_lang=en&sid=1
Ali
Borhani
10031947532846002633
10031947532846002633
No
Student of Pharmacy Department, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Alireza
Vahidi
10031947532846002634
10031947532846002634
No
Assistant Prof, of Pharmacy department / Herbal Medicine Research Center, School of Pharmacy; Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
F. Heidarian
pour
10031947532846002635
10031947532846002635
No
Msc Student of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Elham sadat
Hejazian
10031947532846002636
10031947532846002636
No
Msc Student of Sport Physiology, Azad University of Yazd, Iran
Zahra
Dehestani
10031947532846002637
10031947532846002637
No
Msc Student of Sport Physiology, Azad University of Yazd, Iran
Seyed Hasan
Hejazian
10031947532846002638
10031947532846002638
Yes
Msc Student of Sport Physiology, Azad University of Yazd, Iran