en عمومى General پژوهشي Research Purpose: Pubertal disorders are well known Complications of beta thalassemia Major (TM.( . The aim of study was to assess the effect of sex steroid administration on thalassemic patient attending Boo Ali Sina Hospital, Sari, Iran. Materials and Methods: all of the TM patients at Growth Clinic from 2005 to 2011 were underwent treatment with ethinylestradiol 2.5 to 25 m g/ day plus medroxy progesterone acetate 5mg/day for 15 days of each month for females, or testosterone enenthate 50 –l00 m g / month as IM injection for males. Weight, height, pubertal stage of the subjects was recorded before and after the intervention. Thyroid function, serum ferritin, Ca , P, ALP , LFT, OGTT tests were performed. Compliance to treatment measured by looking at missed visits. Results: 173 TM Patients (54% Female) were followed, age at study in girls and boys were 14± 3.5 and 14.3 ± 2.5 years respectively. Follow up period for girls and boys were 3± 1.2 and 3.3±1.5 years respectively. Increasing of BW SDS and BH SDS in both sexes were statistically significant (P<0.01). SMR changes by McNemar test was significant only in girl (p<0.01). Compliance to treatment was better in girls. Discussion: Sex steroids are cheap and available treatment for growth and pubertal disorders in TM patients. Compliance to treatment is essential for successful treatment. Beta thalassmia major, puberty, Sex steroids, Treatment 0 0 http://intjmi.com/browse.php?a_code=A-10-1-3&slc_lang=en&sid=1