International Journal of Medical Investigation
Int J Med Invest
Medical Sciences
http://intjmi.com
1
admin
2322-2913
2345-640x
no
no
14
8888
13
en
jalali
1391
9
1
gregorian
2012
12
1
1
1
online
1
fulltext
en
COMPARISON OF SALIVARY IGA, TEAR IGA AND SERUM IGE IN PATIENTS SUFFERING FROM CHRONIC RHINOSINUSITIS
تخصصي
Special
پژوهشي
Research
Objective Chronic rhinosinusitis is one of the most common inflammatory diseases around the world which imposes two percent of the world population. Studying the impact of chronic inflammation on immunoglobulin production is a subject of different investigations. This study conducted to evaluate the effect of chronic inflammation on secretory immunoglobulin production and allergic reaction. Therefore, in the current research, we compared salivary IgA, tear IgA and serum total IgE levels of patients suffered from chronic rhinosinusitis with normal subjects to reveal the up regulation of these immunoglobulins in chronically inflamed mucosa.
Patients and Method we monitored immunoglobulins levels of 28 participants including 14 patients with chronic rhinosinusitis and 14 normal control which assayed by Elisa for total IgE and direct immunoenzymatic determination for salivary IgA and tear IgA.
Result there were no significant changes in these immunoglobulin levels as compared to controls. P value of salivary IgA was 0.963, for tear IgA, it was P=0.862 and for serum IgE became P=0.068.
Conclusion Our study indicated that allergic reaction and mucosal immunity mediated by salivary, lacrimal IgA and serum IgE didn’t play an important role in chronic inflammation.
Rhinosinusitis, salivary IgA, tear IgA, total IgE
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http://intjmi.com/browse.php?a_code=A-10-1-4&slc_lang=en&sid=1
Seyyed Abbas
Hashemi
1003194753284600303
1003194753284600303
No
Faculty of medicine
Saeid
Abediankenari
1003194753284600304
1003194753284600304
Yes
Microbiology and Immunology department, Faculty of Medicine, Mazandaran university of medical sciences, Sari IRAN
Seyyed
Madani
1003194753284600305
1003194753284600305
No
ENT department, Faculty of Medicine, traditional and complementary medicine research center, Mazandaran university of medical sciences, Sari IRAN
Mohammad
Akbari
1003194753284600306
1003194753284600306
No
Microbiology and Immunology department, Faculty of Medicine, Mazandaran university of medical sciences, Sari IRAN