fa عمومى General مروری Review <strong>Introduction</strong>: One of the most popular medical drugs with&nbsp; healing&nbsp; ability is Epsom salt&nbsp; that is&nbsp; hydrated magnesium sulphate;MgSo4.7H2o.&nbsp;&nbsp; Magnesium&nbsp; is the fourth most abundant&nbsp; mineral&nbsp; in the body and the second intracellular cation after potassium. In minute amounts it is necessary for body&rsquo;s proper metabolism&nbsp; and function. Magnesium homeostasis in the body is maintained by a delicate interplay among intestinal absorption, skeletal resorption, renal reabsorption and urinary excretion. At cellular level magnesium is a cofactor as well as an activator&nbsp;&nbsp; in almost all enzymatic systems that regulates diverse biochemical reactions in the body. In addition, magnesium is essential for&nbsp; the&nbsp; conversion of vitamin D&nbsp; into its active form&nbsp; which in turn activated vitamin D can increase intestinal absorption of magnesium&nbsp; and calcium influencing the growth and maintenance of bones. Serum magnesium concentration estimation is a poor predictor of intracellular magnesium content and may not accurately reflect the status of body&rsquo;s total magnesium content. The present article will review&nbsp; magnesium deficiency&nbsp; and its&nbsp; role in&nbsp;&nbsp; vitamin D activations.<br> &nbsp;<br> <strong>Methods</strong>: An integrated review format was chosen for present article and many medical and scientific literature on magnesium and its essential role in health and interaction/s with vitamin D were reviewed.<br> &nbsp;<br> <strong>Findings</strong>: Results indicated that chronic magnesium deficiency&nbsp;&nbsp; is common among the general population&nbsp; as well as in the hospitalized patients. It may induce a wide range of clinical complications. Investigations&nbsp;&nbsp; have&nbsp; indicated that the activities of three major vitamin D converting enzymes and vitamin D binding proteins are magnesium dependent. Furthermore, magnesium deficiency leads to reduced 1,25(OH)2 vitamin D and impaired parathyroid response.&nbsp; In general, the effectiveness of vitamin D is significantly reduced when magnesium homeostasis in the body is not maintained.<br> &nbsp;<br> <strong>Conclusion: </strong>It is concluded that chronic magnesium deficiency should always be considered in different clinical complications. Taking magnesium supplementations could be beneficial to prevent recurrence of&nbsp; the diseases.&nbsp; Moreover, the general population should be encouraged&nbsp; to consume magnesium-containing foods to reduce disease burden.&nbsp;&nbsp; Further investigations are necessary in regard to&nbsp; vitamin D and magnesium interaction/s. They may include observations&nbsp; to determine the adequate&nbsp; magnesium dose&nbsp; as well as&nbsp; studies on the&nbsp; more effective type of magnesium supplementation for vitamin D processing. Epsom salt, Chronic magnesium deficiency, Vitamin D, Magnesium supplementation 1 8 http://intjmi.com/browse.php?a_code=A-10-1-282&slc_lang=fa&sid=1 Mehri Aliasgharpour 10031947532846003240 10031947532846003240 Yes Iran Ministry of Health & Medical Education, Reference Health Laboratory, Faculty member of Biochemistry Laboratory.