fa عمومى General مروری Review Multiple Sclerosis (MS) is an autoimmune, inflammatory, and chronic disease that develops due to Myelin destruction lesions in the white matter of the brain, the spinal cord and the optic nerve. Due to the impact of the effect of cognition and the epidemiology of MS, our aim is to review the epidemiology of MS.  In this review, by using keywords including Multiple Sclerosis and through searches on valid scientific databases such as Google Scholar, PubMed, ScienceDirect, Web of Science, Ovid Medline and WHO site, articles and dissertations from 1990 to 2019 were found and reviewed. The studies show that many factors such as age, gender, geographical location, etc. influence the increasing incidence of MS. In this review, we aimed to review the epidemiology of MS. Multiple Sclerosis, Epidemiology, Chronic Disease, Central Nervous System 9 15 http://intjmi.com/browse.php?a_code=A-10-1-285&slc_lang=fa&sid=1 Payam Saadat 10031947532846003225 10031947532846003225 No 1. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Department of Neurology, Babol University of Medical Sciences, Babol, Iran Seyed Mohammad Masood Hojjati 10031947532846003226 10031947532846003226 Yes 1. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Department of Neurology, Babol University of Medical Sciences, Babol, Iran Ali Alizadeh Khatir 10031947532846003227 10031947532846003227 No 1. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Department of Neurology, Babol University of Medical Sciences, Babol, Iran Alijan Ahmadi Ahangar 10031947532846003228 10031947532846003228 No 1. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Department of Neurology, Babol University of Medical Sciences, Babol, Iran Hoda Naghshineh 10031947532846003229 10031947532846003229 No 1. Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Department of Neurology, Babol University of Medical Sciences, Babol, Iran