en تخصصي Special پژوهشي Research Fatigue is one of the most symptoms and main causes of im­paired quality of life in multiple sclerosis (MS)patients.The aim of this study is to determinationrelationship between fatigue with gender, age and disease duration in MS patients. A descriptive, cross-sectional, designed survey was undertaken.Patients’ demographic information collectedandaskedthem to complete Visual Analogue Scale of fatigue status on the ‘day of assessment’ (VAS-F) and theFatigue Impact Scale for Daily Use(D-FIS)questionnaire.Data were analyzed by using SPSS software (version 16.0).Our study included 57 MS patients with mean age of 33.42±8.21 years. Female to male ratio was 2.56. The mean age of the MS onset was 29.58±7.51 years. The duration of MS disease was 3.80±3.35 years. 52 patients (91.22 %) reported fatigue. The mean±SD of VAS-F score was 46.14±25.96mm. We observed a significant positive correlation between VAS score with MS duration (r=0.301, P=0.003) and age of MS onset (r=0.216, P= 0.022). Mean of D-FIS score was 12.75±8.68. Male patients has a significant higher D-FIS score (17.50±9.65 vs. 10.90±7.62) (P=0.009). We observed a significant positive correlation between the D-FIS score with MS duration (r=0.237, P=0.027), age of MS onset (r=0.347, P= 0.008) and gender (r=0.345, P=0.009). The age of onset disease, disease duration and male gender have a positive significant correlation with higher fatigue impact in multiple sclerosis patients. D-FIS, FATIGUE, MULTIPLE SCLEROSIS, VAS-F 0 0 http://intjmi.com/browse.php?a_code=A-10-1-33&slc_lang=en&sid=1 Mehran Fazli 1003194753284600863 1003194753284600863 No Faculty of medicine, Student research committee, Mazandaran University of medical sciences, Sari, Iran Masoud Shayesteh-Azar 1003194753284600864 1003194753284600864 Yes Department of Orthopedic Surgery, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.