Journal of Emergency Health Care
J Emerg Health Care
Medical Sciences
http://intjmi.com
1
admin
3092-6319
3092-6319
10.22034
en
jalali
1393
3
1
gregorian
2014
6
1
3
2
online
1
fulltext
en
IMPACT OF GENETIC POLYMORPHISM OF ABCB1 (MDR1) 2677G>T –A IN KIDNEY DONORS ON TACROLIMUS LEVEL IN JORDANIAN KIDNEY TRANSPLANT RECIPIENTS DURING THE EARLY POST TRANSPLANTATION PERIOD
عمومى
General
پژوهشي
Research
The aim of this study was to determine the role of donors’ ABCB1 G2677T/A polymorphism on tacrolimus dose requirements, trough levels and dose-adjusted trough concentrations among Jordanian renal transplant recipients during the early, unstable period post transplantation.Donors of those renal transplant recipients who were started on tacrolimus post-transplantation (n=53) were genotyped for MDR1 G2677T/A using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis. Tacrolimus doses (mg/kg body weight), trough concentrations (ng/ml), dose-adjusted trough concentrations (ng/ml per mg/kg body weight) were compared among patients according to donors’ allelic status for MDR1 (G2677T/A). Among the 53 donors, 28 (52.8%) were carriers of GG, 20 (37.7%) of GT, and 5 (9.4%) of TT MDR1 alleles. Trough tacrolimus concentrations in recipients of donors carrying at least one T mutant alleles (2677TT or 2677GT, serine phenotype) did not differ significantly from trough concentration in recipients of donors carrying homozygote wild, 2677GG genotype (alanine) during the early 6 months post renal transplantation (P = 0.40, 0.62, 0.42, 0.60, 0.93, 0.66 for months 1-6, respectively). In conclusion, donor’s MDR1 gene polymorphism has no impact on trough tacrolimus concentration during the early period post-transplantation. To date, the results of studies remain controversial and many other factors must be considered to predict variability profile of trough tacrolimus levels accurately.
Tacrolimus, dose requirements, trough levels, dose-adjusted trough concentrations
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http://intjmi.com/browse.php?a_code=A-10-1-44&slc_lang=en&sid=1
Ahmad Masadeh
1003194753284600608
1003194753284600608
Yes
King Hussein Medical Centre, Royal Medical Services, Amman, Jordan
Nailya Bulatova
1003194753284600609
1003194753284600609
No
Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Al-Motassem Yousef
1003194753284600610
1003194753284600610
No
Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Tareq Abu-Al ganam
1003194753284600611
1003194753284600611
No
King Hussein Medical Centre, Royal Medical Services, Amman, Jordan