en عمومى General پژوهشي Research Background . Growing evidence suggests that diet rich in bioactive compounds proven to have a general protective effects on health and especially on cancer and cardiovascular diseases prevention. Lemon and garlic are among these compounds and health claims regarding lipids lowering benefits of them are widespread. In the present work the lowering effects of lemon and fresh garlic liquid mixture on serum lipids level were studied . Material &Methods . A total of n=45 mild hypercholesterolemic women ( cholesterol level>230mg/dL) was assessed. Based on the filed questionnaires n=15 were excluded and the rest randomized into 2 groups treatment & control . Subjects were intervened to use either 150mL of the lemon and fresh garlic liquid mixture or water after lunch for a total period of 8 weeks. Measurements of fasting levels of cholesterol, low density lipoprotein, high density lipoprotein , and triglycerides were made at baseline and 8 weeks after. A 7.7% reduction in total cholesterol , 10.7% in LDL , and 11.7% in triglycerides in treatment group were obtained ( paired T test p=0.001) . HDL levels remained unchanged in both groups (treatment & control). Conclusions. It is concluded that use of this combined mixture attributes to dietary supplementation to lower serum lipids level in mild hypercholesterolemic women and may provide benefits on reducing cardiovascular diseases risk factors in this population .To further clarify the lowering effects of this mixture in specific groups including hypercholesterolemic men and women studies with large sample size are needed . Total Cholesterol, Low Density Lipoprotein, High Density Lipoprotein, Triglycerides, Organosulfur, and Flavonoids. 0 0 http://intjmi.com/browse.php?a_code=A-10-1-46&slc_lang=en&sid=1 Mehri Aliasgharpour 1003194753284600619 1003194753284600619 Yes Department of Clinical Biochemistry