International Journal of Medical Investigation
Int J Med Invest
Medical Sciences
http://intjmi.com
1
admin
2322-2913
2345-640x
no
no
14
8888
13
en
jalali
1401
4
1
gregorian
2022
7
1
11
2
online
1
fulltext
fa
Successful Treatment of Trichosporon asahii Infection with Combination
Therapy of Voriconazole and Liposomal Amphotericin B in a Child with
Acute Lymphoblastic Leukemia: A Case Report
عمومى
General
پژوهشي
Research
Background: Trichosporon species (particularly T. asahii) is regarded as one of the prevalent fungal species responsible for causing invasive fungal infection in patients with hematological malignancies and/or immunocompromised patients. Trichosporonosis can often be life-threatening; therefore, an early diagnosis followed by prompt treatment is crucial for the patient’s survival. However, an ideal antifungal treatment for T. asahii infection is not yet established. Case Presentation: This report presented a case of T. asahii fungemia in a male child of age 5-year 5 months with acute lymphoblastic leukemia. The patient developed febrile neutropenia towards the end of induction chemotherapy, and his blood culture indicated the presence of T. asahii and E. coli. He was treated with broad-spectrum antibiotics and antifungal monotherapy (either liposomal amphotericin B or voriconazole) without an effective outcome. Subsequently, the patient further underwent combination therapy with voriconazole and liposomal amphotericin B. Conclusion: Combination therapy with voriconazole and liposomal amphotericin B was found to improve the condition of the patient. He is currently reported to be fine while undergoing maintenance chemotherapy along with voriconazole monotherapy
Amphotericin B, Antifungal Agents, Chemotherapy, Febrile Neutropenia, T. asahii,
voriconazole.
157
166
http://intjmi.com/browse.php?a_code=A-10-1-464&slc_lang=fa&sid=1
Maha Jassim
Bourusly
10031947532846005049
10031947532846005049
Yes
Department of Hematology, Oncology and Stem Cells Transplant, NBK Children’s Specialty Hospital, MOH. Kuwait.
Mohammed
Adel Obaid
10031947532846005050
10031947532846005050
No
Department of Hematology, Oncology and Stem Cells Transplant, NBK Children’s Specialty Hospital, MOH. Kuwait.
Muna
Burahma
10031947532846005051
10031947532846005051
No
Department of Hematology, Oncology and Stem Cells Transplant, NBK Children’s Specialty Hospital, MOH. Kuwait.