OTHERS_CITABLE IMPACT OF GENETIC POLYMORPHISM OF ABCB1 (MDR1) 2677G>T –A IN KIDNEY DONORS ON TACROLIMUS LEVEL IN JORDANIAN KIDNEY TRANSPLANT RECIPIENTS DURING THE EARLY POST TRANSPLANTATION PERIOD The aim of this study was to determine the role of donors’ ABCB1 G2677T/A polymorphism on tacrolimus dose requirements, trough levels and dose-adjusted trough concentrations among Jordanian renal transplant recipients during the early, unstable period post transplantation.Donors of those renal transplant recipients who were started on tacrolimus post-transplantation (n=53) were genotyped for MDR1 G2677T/A using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis. Tacrolimus doses (mg/kg body weight), trough concentrations (ng/ml), dose-adjusted trough concentrations (ng/ml per mg/kg body weight) were compared among patients according to donors’ allelic status for MDR1 (G2677T/A). Among the 53 donors, 28 (52.8%) were carriers of GG, 20 (37.7%) of GT, and 5 (9.4%) of TT MDR1 alleles. Trough tacrolimus concentrations in recipients of donors carrying at least one T mutant alleles (2677TT or 2677GT, serine phenotype) did not differ significantly from trough concentration in recipients of donors carrying homozygote wild, 2677GG genotype (alanine) during the early 6 months post renal transplantation (P = 0.40, 0.62, 0.42, 0.60, 0.93, 0.66 for months 1-6, respectively). In conclusion, donor’s MDR1 gene polymorphism has no impact on trough tacrolimus concentration during the early period post-transplantation. To date, the results of studies remain controversial and many other factors must be considered to predict variability profile of trough tacrolimus levels accurately. http://intjmi.com/article-1-64-en.pdf 2014-12-01 0 0 Tacrolimus dose requirements trough levels dose-adjusted trough concentrations Ahmad Masadeh 1 King Hussein Medical Centre, Royal Medical Services, Amman, Jordan AUTHOR Nailya Bulatova 2 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan AUTHOR Al-Motassem Yousef 3 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan AUTHOR Tareq Abu-Al ganam 4 King Hussein Medical Centre, Royal Medical Services, Amman, Jordan AUTHOR
OTHERS_CITABLE RISK FACTORS OF INFECTION FOLLOWING ORTHOPEDIC SURGERIES AT AN ACADEMIC HOSPITAL SARI – IRAN Objective: Nasocomial infections are the group of infections that afflict the patient that are admitted in the hospital. The aim of this study was to evaluate the infection rate after the orthopedic surgeries. Material and Methods: A cross-sectional study conducted in all of the hospitalized objects at orthopedic ward of Imam Khomeini hospital Sari-Iran during 2012. Results: Among 1024 patients whom were examined 40 patients had postoperative complications (28 male and 12 female). There were no significant changes between the mean age of men versus women (p=0.64). In this regard there were no differences between the times of hospitalization between these groups (0.78). The mean time of postoperative infections in men was 88.7±72.1 and in women was 86.3±75 (p=0.43). Smoking was the most common risk factor went after by diabetes and hypertension. Conclusion: The rate of postoperative infections in this center was the same as another part of the world. http://intjmi.com/article-1-65-en.pdf 2014-12-01 0 0 Infection Orthopedics Surgery Mohammad Hossein Kariminasab 1 Assistant Professor of Department of Orthopedic, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR Majid Sajadi Saravi 2 Assistant Professor of Department of Orthopedic, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR Masoud Shayesteh Azar 3 Associate Professor, Department of Orthopedic, Fellowships of Hip, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR Mehrdad Taghipoor 4 MD, Baqiatallah University of Medical Sciences, Tehran, Iran AUTHOR Milad Bahari 5 Medical Student, Faculty of medicine, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR Oveis Sharifian 6 MD, Baqiatallah University of Medical Sciences, Tehran, Iran AUTHOR Shadi Shayesteh Azar 7 Medical Student, Faculty of medicine, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR
OTHERS_CITABLE LOWERING EFFECTS OF LEMON AND FRESH GARLIC LIQUID MIXTURE ON SERUM LIPIDS LEVEL IN HYPERCHOLESTEROLEMIC WOMEN Background . Growing evidence suggests that diet rich in bioactive compounds proven to have a general protective effects on health and especially on cancer and cardiovascular diseases prevention. Lemon and garlic are among these compounds and health claims regarding lipids lowering benefits of them are widespread. In the present work the lowering effects of lemon and fresh garlic liquid mixture on serum lipids level were studied . Material ;Methods . A total of n=45 mild hypercholesterolemic women ( cholesterol level>230mg/dL) was assessed. Based on the filed questionnaires n=15 were excluded and the rest randomized into 2 groups treatment & control . Subjects were intervened to use either 150mL of the lemon and fresh garlic liquid mixture or water after lunch for a total period of 8 weeks. Measurements of fasting levels of cholesterol, low density lipoprotein, high density lipoprotein , and triglycerides were made at baseline and 8 weeks after. A 7.7% reduction in total cholesterol , 10.7% in LDL , and 11.7% in triglycerides in treatment group were obtained ( paired T test p=0.001) . HDL levels remained unchanged in both groups (treatment & control). Conclusions. It is concluded that use of this combined mixture attributes to dietary supplementation to lower serum lipids level in mild hypercholesterolemic women and may provide benefits on reducing cardiovascular diseases risk factors in this population .To further clarify the lowering effects of this mixture in specific groups including hypercholesterolemic men and women studies with large sample size are needed . http://intjmi.com/article-1-66-en.pdf 2014-12-01 0 0 Total Cholesterol Low Density Lipoprotein High Density Lipoprotein Triglycerides Organosulfur and Flavonoids. Mehri Aliasgharpour 1 Department of Clinical Biochemistry AUTHOR
OTHERS_CITABLE FREQUENCY OF POSTOPERATIVE ACCOMPANYING PARATHYROIDECTOMY RISK FACTORS IN JORDANIAN POPULATION. OUR EXPERIENCE AT KING HUSSEIN MEDICAL CITY To evaluate the frequency and risk factors of unintentional parathyroidectomy after thyroidectomy in our Jordanian population.This retrospective investigation enrolled 103 subjects assigned for thyroidectomy at King Hussein Hospital, King Hussein medical city, Amman, Jordan during the period Jan 2012- Aug 2013.The patient’s demographics reported age, sex, preoperative FNA diagnosis and postoperative histopathological reports. The thyroid surgical procedure (subtotal or total thyroidectomy with lobectomy or completion thyroidectomy) was achieved by senior surgeons. Histopathology reports were reviewed for the presence and characteristics of parathyroid tissue glands and thyroid pathology. For statistical analysis, the chi-square test and Fisher exact test were used to evaluate statistical significance. P≤.05 was be considered statistically significant.Eleven (11) subjects (10.7 %) had their parathyroid glands incidentally removed.There was significant difference between the mean age of patients with and without accompanying parathyroidectomy (35.5 vs. 50 years, P≤0.05).Nine (81.8%) patients with accompanying parathyroidectomy had only one parathyroid gland excised, one patient (9.1 %) had two removed and one patient (9.1 %) had three removed.The frequency of accompanying parathyroidectomy after thyroidectomy was 10.7% which is within the international limits.Risk factors were female sex, lobectomy thyroidectomy and multinodular goiter. http://intjmi.com/article-1-67-en.pdf 2014-12-01 0 0 factors Jordan thyoidectomy parathyroidectomy accompanying Omar abuelaish 1 AUTHOR Ali Alobus 2 AUTHOR Saleh habahbeh 3 AUTHOR Majdi soudi 4 AUTHOR Raed aljarrah 5 AUTHOR
CASE_STUDY CONGENITAL BILATERAL RADIOULNAR SYNOSTOSIS Congenital RadioulnarSynostosisis a bony connection between the radius and ulna. In 1793 for the first time Sandifort explained the initial description of congenital radialulnarsynostosis[1,2]. The condition may be unilateral or bilateral that is more common. Functional defects associated with the anomaly depend on the severity of the deformity and on whether or not it is bilateral[3,4,5]. The condition may associate with other abnormalities and syndromes but we didn’t find in our patient any of them[6-11]. Important view of this manuscript was rarity of this anomaly and also in patient opinion is unimportant disturbance that caused him didn’t refer to specialist since long past. http://intjmi.com/article-1-68-en.pdf 2014-12-03 0 0 factors Radioulnar Synostosis Congenital bony connection Mohamadhosseinkariminasab 1 Assistant professor of Mazanadaran university of medical science, orthopaedic department, imam Khomeini hospital AUTHOR MasoudShayeste-Azar 2 Associate professor of Mazanadaranuniversity of medical science, orthopaedic department, imam Khomeini hospital AUTHOR MajidSajjadisaravi 3 Assistant professor of Mazanadaran university of medical science, orthopaedic department, imam Khomeini hospital AUTHOR SeyedMohamad Mehdi Daneshpoor 4 Orthopaedic resident, Mashhad university of medical science, orthopaedic department, emamreza hospital AUTHOR shadiShayeste-Azar 5 medical student,Mazanadaranuniversity of medical science AUTHOR
OTHERS_CITABLE CITATION AND SELF-CITATION RATES OF IRANIAN AND TURKISH JOURNALS INDEXED IN ISI In recent years,the growth rate of scientific production is increasing noticeabley.Citation analysis is currently one of the most widely used metrics for analyzing the scientific contribution of any units. Self-citation is a common practice but it can differ between disciplines, countries and journals. In this study we evaluated the impact factor (IF), citations and self-citations of Iranian and Turkish journals indexed in Web of Science based on the Journal Citation Report(JCR) 2012. We used the ISI-database journal citation report from Thomson-Reuters, JCR 2012, to collectjournals` impact factors, number of articles, number of citations and self-citationsfor both Turkey and Iran from 2009 to 2010 (which was used to calculate the impact factor of 2011). The mean, median and percentiles of each variableswere compared between countries using theIndependent Student t-test or Mann-Whithney U test in the case of violation of normal distribution. In addition therelationship between the number of publicationsand impact factor was studied by using the pearson correlation coefficient. Based on the 2012 JCR report, the total number of Iranian and Turkish articles were 4017 and 7260 respectively and themean self-citations were 26% for journals from both countries. The median of total IF was greater in Iranian journals as opposed to the Turkish one’s, 0.466 vs 0.349. The figure was similar for IF without self-citations, 0.330 vs 0.243, however both differences were statistically non-significant, p-values>0.05.A significant correlation was seen between the number of published articles and IF without self-citationsfor Iranian journals, r=0.342 and p-value=0.034. Although self-citation is quite high in both countries, Iranian journals had higher IF (total and without self-citation) compared to the Turkish journals. http://intjmi.com/article-1-69-en.pdf 2014-12-03 0 0 Citation self-citation Iranian journal Turkish journal ISI Safoora Masoumi, Zahra Foroughi 1 AUTHOR Mohsen Arabi 2 AUTHOR Leila Shokohi 3 AUTHOR Fateme Ghaffari 4 AUTHOR Saravi, Ensieh Taghizadeh 5 AUTHOR Reza Alizadeh-Navaei 6 AUTHOR hojjatolah bahrami 7 AUTHOR
OTHERS_CITABLE ANOMALOUS LEFT CORONARY ARTERY FROM PULMONARY ARTERY PRESENTING ASSOCIATED WITH ISOLATED CLEFT PALATE Anomalous Left Coronary Artery from the pulmonary artery (ALCAPA) is a rare congenital cardiac anomaly accounting for approximately 0.25%-0.5% of all congenital heart diseases. This anomaly is usually isolated, but has been associated with patent ductus arteriosus (PDA), ventricular septal defect (VSD), tetralogy of fallot (TOF) or coarctation of the aorta (COA). This anomaly hasn’t been associated with extracardiac anomaly.Here we reported a 2-year of old male with cleft palate and the ALCAPA, who presented with cardiomegaly and patent ductus arteriosus. As the early diagnosis of ALCAPA is important, we suggest this association consider in the cleft palate population with congenital heart disease. AS the delay of ALCAPA diagnosis may be associated to elevated mortality and morbidity of cleft palate repair, we suggest ALCAPA association was carefully searched in the cleft palate population http://intjmi.com/article-1-70-en.pdf 2014-12-03 0 0 Anomalous left coronary artery pulmonary artery patent ducts arteriosus cleft palate. Asadollah Tanasan 1 Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran AUTHOR Ahmad Jamei Khosroshaei 2 Department of Pediatric, Faculty of Medicine, Tabriz University of Medical Sciences and Health Services, Tabriz, Iran AUTHOR Farshad rostampour 3 Student Research Committee (SRC), Faculty of Medicine, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran AUTHOR Poya Tanasan 4 Medical Student, Faculty of Medicine, Tehran University of Medical Sciences and Health Services, Tehran, Iran AUTHOR
CASE_STUDY ESOPHASIAL MELANOSIS Esophageal melanosis is a benign clinicopathologic diagnosis which it has been said more common in Asian than western population. In this entity melanin deposition in mucosa with an increased melanocytic proliferation can be realized . Its etiology is unknown but it is doubtful to be one of the precursors of esophageal melanoma . We aimed to represent and review histopathologic features of a case of melanosis. A 80 year old woman with long time history of dyspepsia referred to endoscopy department. There was a past history of reflux disease that under histopathologic evaluation and immunohistochemical staining it turned out to be brownish melanocyte proliferation Esophageal melanosis is a rare benign histopathologic lesion and it has been suggested as a melanoma precursor. Thus, making an accurate diagnosis and patient follow up are recommended. http://intjmi.com/article-1-71-en.pdf 2014-12-03 0 0 Esophagus Melanocyte Melanosis IHC HMB45 S100. Anahita Nosrati 1 Assistant professor, department of pathology, Imam Hospital , Mazandaran University of Medical Science, Sari, Iran Medical Science, Sari, Iran. AUTHOR Zhila Torabizadeh 2 Associate professor, department of pathology, Imam Hospital , Mazandaran University of Medical Science, Sari, Iran Medical Science, Sari, Iran. AUTHOR Shadi Tahvildari 3 Residence of pathology ,department of pathology, Imam Hospital , Mazandaran University of Medical Science, Sari, Iran. AUTHOR Milad Bahari 4 Medical Student of Faculty of medicine, student research committee, Mazandaran University Of Medical Sciences, Sari, Iran AUTHOR
CASE_STUDY FEMALE URETHRAL LEIOMYOMA A MIMICKER OF CARUNCLE Benign tumors of urethra may emanate from any urethral compartment. Leiomyoma of female urethra arising from the smooth muscle and mostly presented in woman between 30-40 years and it is a rare tumor coming into different clinical views. Tumor size varies from 1 to 8 cm. The lesion is hormonally sensitive. Patients can present with a mass around urethra, urinary infection, dyspareunia and hematuria. We report the first case of benign female urethral leiomyoma mimicking a caruncle in our department. http://intjmi.com/article-1-72-en.pdf 2014-12-03 0 0 Urethral leiomyoma Female urethra Spotting Caruncle Anahita Nosrati 1 AUTHOR Zhila Torabizadeh 2 AUTHOR Behkam Rezaimehr 3 AUTHOR Milad Bahari 4 AUTHOR
CASE_STUDY DOUBLE OUTLET RIGHT VENTRICLE WITH PULMONARY VALVE STENOSIS IN A YOUNG GIRL http://intjmi.com/article-1-73-en.pdf 2014-12-03 0 0 Vida Nesarhosseini 1 Assistant Professor, Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran AUTHOR Mehrdad Taghipour 2 Baqiyatallah University of Medical Sciences, Tehran, Iran AUTHOR Fariborz Azizi 3 Mazandaran University of Medical Sciences, Sari, Iran AUTHOR
CASE_STUDY POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME IN A YOUNG WOMAN Posterior reversible encephalopathy syndrome)PRES( is aclinicoradiologic entity that characterized by variable associations of seizure activity ,consciousness impairment, headache, nausea/vomiting and visual abnormalities.It has certain characteristic radiological features, which allow diagnosis by the clinical findings .PRES has been associated with chronic renal disease,preeclampsia,eclampsia,SLE and administration of immunosuppressive agents. Case Report: A 25-year-old woman was hospitalized due to headache, nausea/vomiting, acute visual disturbance and consciousness impairment (lethargy).She was developed generalizetonic clonic seizure. She had been admitted several times over a 5 month period with kidney stones and renal failure, so she was undergoing dialysis program because of ESRD. Her initial blood pressurewas 150/90 mmHg. Bilateral pupils mydriasis with weak light reflex and bilatral papilledema were detected. In motor examination, left limbs movements were slower than right limbs and Bilateral up plantar reflexes were detected .Admission Bun:54 and Cr:7.8 but the other laboratory data were in normal ranges .MRI findings demonstrated bilateral and symmetrical high signal intensity change in white matter of occipital and parietal lobes. Conclusion: The pathogenesis of PRES is based on theory that the elevated blood pressure above patient`s baseline ,exceeds the cerebral vascular auto regulatory abilities, results in vasogenic edema in brain parenchyma and the posterior sub cortical white matter is commonly involved. In many cases also in our case, clinical and radiological recovery of PRES seems to be occure within a period of days to weeks, after removal of the inciting factor and control of blood pressure . http://intjmi.com/article-1-74-en.pdf 2014-12-03 0 0 PRES ESRD Seizure Masoud Ghiasian 1 Assistant Professor, Department of Neurology , Hamadan University of Medical Sciences & Health Services, Hamadan, Iran. AUTHOR Zeinab Bagheri 2 Medical student , Hamadan University of Medical Sciences & Health Services, Hamadan, Iran. AUTHOR Mohammad Amin Fereydouni 3 3Student Research Committee, Hamedan University of Medical Sciences, Hamedan AUTHOR
CASE_STUDY ACUTE HYPOKALEMIC PERIODIC PARALYSIS AFTER INTRAVENOUS ADMINISTRATION OF METHYLPREDNISOLONE IN PATIENT WITH GRAVES’ THYROTOXICOSIS Acute hypokalemic periodic paralysis after intravenous administration of methylprednisolone in patient with graves’ thyrotoxicosis: A letter to editor http://intjmi.com/article-1-75-en.pdf 2014-12-03 0 0 Seyyed Javad Kiani 1 AUTHOR Mohammad Amin Fereydouni 2 AUTHOR Mehrdad Taghipour 3 AUTHOR Fariborz Azizi 4 AUTHOR Lotfollah Davoodi 5 AUTHOR Reza Maleki Gorji 6 AUTHOR