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:: Volume 10, Issue 3 (9-2021) ::
Int J Med Invest 2021, 10(3): 0-0 Back to browse issues page
Evaluation Of Various Progesterone Therapy Routes For Luteal Phase Support In IVF: A Systematic Review And Meta-Analysis
Majid Vatankhah, Arman Hakemi, Fatemeh Rahmanian, Somayeh Hoseini, Samaneh Abiri, Farideh Mogharab, Lohrasb Taheri, Rezvan Heidari, Marzieh Haghbeen *
Women’s Health and Disease Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Abstract:   (196 Views)
The progesterone secreted from the ovary until the seventh week of pregnancy is required to maintain pregnancy. In fertility-assisted cycles, administration of GnRH agonists, can cause Corpus luteum failure and progesterone secreted from the ovary will not be sufficient to protect pregnancy. The best way to prevent this situation is support progesterone administration.
Objective: this study aimed to rank the best route of progesterone administration in luteal phase support.
Randomized controlled trials (RCTs) of progesterone for the luteal phase support were identified from online databases of Scopus, Google Scholar, Pubmed. Treatment efficacy was defined as ongoing pregnancy.  Data were extracted and analyzed using odds ratios (ORs). A Bayesian network meta-analysis was performed using the Markov chain Monte Carlo method in WinBUGS and NetMetaXL.
Total 1176 participants were studied in 16 trials of 6 separate progesterone routes including vaginal progesterone gel, progesterone sub q, Dydrogesterone, Cap 200 mg TID, Cap 200 mg BID, and progesterone IM. Comparison test shows better likelihood of SUCRA followed by vaginal progesterone gel (77.8%), progesterone sub q (55.49%), Dydrogesterone (53.97%), Cap 200 mg TID (50.67%), Cap 200 mg BID (48.99%) and finally progesterone IM (13.06%).
This study ranked as the best route of progesterone therapy for luteal phase support, through the reviewed studies.
Keywords: Network meta-analysis, Progesterone, Luteal Phase Support, IVF.
Type of Study: Review | Subject: General
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Vatankhah M, Hakemi A, Rahmanian F, Hoseini S, Abiri S, Mogharab F, et al . Evaluation Of Various Progesterone Therapy Routes For Luteal Phase Support In IVF: A Systematic Review And Meta-Analysis. Int J Med Invest. 2021; 10 (3)
URL: http://intjmi.com/article-1-645-en.html

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Volume 10, Issue 3 (9-2021) Back to browse issues page
International Journal of Medical Investigation
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