International Journal of Medical Investigation
Int J Med Invest
Medical Sciences
http://intjmi.com
1
admin
2322-2913
2345-640x
no
no
14
8888
13
en
jalali
1398
9
1
gregorian
2019
12
1
8
4
online
1
fulltext
fa
Promising Role of CD200 Expression in Diagnosis and Prognosis of Chronic Lymphocytic Leukemia: A Review
عمومى
General
پژوهشي
Research
One of the most common leukemia in the world is chronic lymphocytic leukemia (CLL). CLL, as an incurable malignant disorder of B-lymphocytes. CD200, formerly known as OX-2, is a type I glycoprotein that is expressed on a variety of cell types. CD200 plays a vital role in the modulation of the immune system and is upregulated on the surface of numerous tumors, including chronic lymphocytic leukemia. In several studies, it is noted that CD200 was upregulated 1.6- to 5.4-fold in B cells from all patients with B-CLL and may suggest that CD200 upregulation is an early event in the B-CLL disease process. It might conclude that CD200 blocking therapy may be beneficial, and several studies have proven this. We can conclude that CD200 is an excellent prognostic factor that expresses in most CLL patients, and antiCD200 therapeutic interventions can be useful. This literature review article was conducted with the purpose of role of CD200 Expression in the Diagnosis of Chronic Lymphocytic Leukemia.
Chronic Lymphocytic Leukemia, Prognosis, CD200, diagnosis
16
22
http://intjmi.com/browse.php?a_code=A-10-1-286&slc_lang=fa&sid=1
Mohammad
Zahedi
10031947532846003230
10031947532846003230
No
1- Department of Laboratory Sciences, School of Allied Medical Science, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Seyedeh Saeede Kadkhodazade
Khorasani
10031947532846003231
10031947532846003231
No
1- Department of Laboratory Sciences, School of Allied Medical Science, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Amirreza
Nasirzadeh
10031947532846003232
10031947532846003232
No
2- Student of Basic Sciences in Nursing, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.
Reza
Abouali
10031947532846003233
10031947532846003233
No
3- Department of Laboratory Sciences, School of Allied Medical Science, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Mahdi
Abounoori
10031947532846003234
10031947532846003234
No
4- Medical Student, Student Research committee, Mazandaran University of Medical Sciences, Sari, Iran
Parham
Mortazavi
10031947532846003235
10031947532846003235
No
5- School of pharmacy, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Reza
Sadeghnezhad
10031947532846003236
10031947532846003236
No
6- Environmental Health Engineering, student research committee, Faculty of Health, Health Sciences Research, Mazandaran University of Medical Sciences, Sari, Iran.
Ali Reza
Mohseni
10031947532846003237
10031947532846003237
Yes
7- Thalassemia Research Center, Hemoglobinopathy institute, Mazandaran University of Medical Sciences, Sari, Iran