Objective: Brucellosis is an zeonotic disease and it is a health and economic problem in many parts of the world, including Iran. The disease is endemic in Iran and the reported cases increased, however, disease outbreaks are not clear. This review aimed to determine the prevalence of brucellosis in normal and high-risk population in Iran.

Methods: This systematic review and meta-analysis was performed in article about Brucellosis in Iran. Systematic search was conducted in the databases, include: Pubmed,  Scopus, SID (as a local database) until August 2015.  Finally we have 454 article after deleting duplicating material by Endnote software. Data extraction form contains author, publication year, sample size, laboratory test, study population in normal person and high risk person and seroprevalence. Finally, Data were analyzed by STATA 11.1 and random effect.

Results: Finally, we enrolled 11 studies and 7688 person in high risk group and 13858 person in normal group were studied. The seroprevalence of brucellosis in normal population was 0.12 (CI95%: 0.08 - 0.17). The seroprevalence of brucellosis in High-risk population was 13.07(CI95%: 12.3 - 13.7).

Conclusion:  The prevalence of  brucellosis in high-risk occupations was high in comparison with normal population and it seems that control of livestock diseases should be considered more.