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Objective: One of the aims of medicine is to heal wounds in a shorter time and with fewer complications. In the studies on the effect of Scrophularia striata Boiss on the probability of mitigation of infection, reduction of the wound healing period, inflammation and scar remaining from the wound have been shown. Gel mask formulation, enjoying PVA polymer, creates a natural scaffold on wounds, causing the cells to migrate in an organized fashion towards the wound's bed and proliferate. By introducing the plant's extract in this base, its effect on reduction of the healing time and mitigation of the scar remaining from the wound becomes predictable. Methods: The total plant was extracted through percolation using ethanol 70%. The plant's standardization was done through determination of the total polyphenols' percentage using folin-ciocalteu reagent. The extract was then concentrated and the amount of the dry extract per each 100 g of the plant's powder was calculated. Next, different formulations with different percentages of PVA, ethanol, isopropyl alcohol, propylene glycol, and glycerin and other substances available in the base were prepared and then evaluated in terms of formation of medicinal film, drying time, pH, and other physiochemical parameters. Thereafter, drug diffusion was investigated using Franz cell and drug diffusion kinetics from the base. Results: The amount of the plant's polyphenols was 25.1% and the amount of the plant's dry extract was 12.5%. The optimal formulation is a clear gel that forms a medicinal film after application of wound and following 10 minutes of use. It contains 7.5% pva, 15% alcohol, 10% isopropyl alcohol, 0.5% xantam, and 3% glycerin. The pH of the formulation was 5.65 and had the stability required in physiochemical evaluations and stability experiments. Drug release was done within 35 min as much as 90%, with the drug's release model following Higuichi model. ConclusionThe optimal gel mask formulation containing 10% the extract of Scrophularia striata Boiss plant indicated a desirable stability in physiochemical evaluation. Considering the synergistic effect of the base and the extract in shortening the wound healing period and mitigation of remaining scar, clinical studies should be conducted.

     

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