Journal of Emergency Health Care
Formerly known as: International Journal of Medical Investigation
Volume 5, Issue 3 (9-2016)
J Emerg Health Care 2016, 5(3): 100-107 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Shatalebi M A, Zolfaghari B, Rashidbeygi M, Morshedi S. Formulation and physiochemical evaluation of honey-containing gel mask, PVA, and total hydro-alcoholic extract of Scrophularia striata Boiss for the healing of minor wound . J Emerg Health Care 2016; 5 (3) :100-107
URL: http://intjmi.com/article-1-243-en.html
URL: http://intjmi.com/article-1-243-en.html
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (9734 Views)
Objective: One of the aims of medicine is to heal wounds in a shorter time and with fewer complications. In the studies on the effect of Scrophularia striata Boiss on the probability of mitigation of infection, reduction of the wound healing period, inflammation and scar remaining from the wound have been shown. Gel mask formulation, enjoying PVA polymer, creates a natural scaffold on wounds, causing the cells to migrate in an organized fashion towards the wound's bed and proliferate. By introducing the plant's extract in this base, its effect on reduction of the healing time and mitigation of the scar remaining from the wound becomes predictable. Methods: The total plant was extracted through percolation using ethanol 70%. The plant's standardization was done through determination of the total polyphenols' percentage using folin-ciocalteu reagent. The extract was then concentrated and the amount of the dry extract per each 100 g of the plant's powder was calculated. Next, different formulations with different percentages of PVA, ethanol, isopropyl alcohol, propylene glycol, and glycerin and other substances available in the base were prepared and then evaluated in terms of formation of medicinal film, drying time, pH, and other physiochemical parameters. Thereafter, drug diffusion was investigated using Franz cell and drug diffusion kinetics from the base. Results: The amount of the plant's polyphenols was 25.1% and the amount of the plant's dry extract was 12.5%. The optimal formulation is a clear gel that forms a medicinal film after application of wound and following 10 minutes of use. It contains 7.5% pva, 15% alcohol, 10% isopropyl alcohol, 0.5% xantam, and 3% glycerin. The pH of the formulation was 5.65 and had the stability required in physiochemical evaluations and stability experiments. Drug release was done within 35 min as much as 90%, with the drug's release model following Higuichi model. ConclusionThe optimal gel mask formulation containing 10% the extract of Scrophularia striata Boiss plant indicated a desirable stability in physiochemical evaluation. Considering the synergistic effect of the base and the extract in shortening the wound healing period and mitigation of remaining scar, clinical studies should be conducted.
References
1. 1. Bucholz RW. Rockwood and Green's fractures in adults: Lippincott Williams & Wilkins Philadelphia; 2006.
2. Gebhard JS, Amstutz HC, Zinar DM, Dorey FJ. A comparison of total hip arthroplasty and hemiarthroplasty for treatment of acute fracture of the femoral neck. Clinical orthopaedics and related research. 1992(282):123-31.
3. Buord J-M, Flecher X, Parratte S, Boyer L, Aubaniac J-M, Argenson J-N. Garden I femoral neck fractures in patients 65years old and older: Is conservative functional treatment a viable option? Orthopaedics & Traumatology: Surgery & Research. 2010;96(3):228-34.
4. Bhandari M, Devereaux P, Swiontkowski MF, Tornetta P, Obremskey W, Koval KJ, et al. Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. The Journal of Bone & Joint Surgery. 2003;85(9):1673-81.
5. Dai Z, Li Y, Jiang D. Meta-analysis comparing arthroplasty with internal fixation for displaced femoral neck fracture in the elderly. Journal of Surgical Research. 2011;165(1):68-74.
6. Aynaci O, Kerimoglu S, Ozturk C, Saracoglu M. Bilateral non-traumatic acetabular and femoral neck fractures due to pregnancy-associated osteoporosis. Archives of orthopaedic and trauma surgery. 2008;128(3):313-6.
7. Carpintero P, Abad JA, Urbano D, Jimenez-Sánchez C. Simultaneous bilateral fracture of femoral neck in elderly patients: report on two cases. European Journal of Orthopaedic Surgery & Traumatology. 2006;16(2):172-4.
8. Jalili A, Saied A. Bilateral Simultaneous Femoral Neck Fractures in a 4 Year Child–a Case Report. Journal of Babol University of Medical Sciences. 2009;11(2):80-3.
9. Gjertsen J-E, Vinje T, Engesaeter L, Lie S, Havelin L, Furnes O, et al. Internal screw fixation compared with bipolar hemiarthroplasty for treatment of displaced femoral neck fractures in elderly patients. The Journal of Bone & Joint Surgery. 2010;92(3):619-28.
10. Murphy DK, Randell T, Brennan KL, Probe RA, Brennan ML. Treatment and displacement affect the reoperation rate for femoral neck fracture. Clinical Orthopaedics and Related Research®. 2013;471(8):2691-702.
11. Leonardsson O, Rolfson O, Hommel A, Garellick G, Åkesson K, Rogmark C. Patient-Reported Outcome After Displaced Femoral Neck Fracture. The Journal of Bone & Joint Surgery. 2013;95(18):1693-9.
12. Tidermark J, Ponzer S, Svensson O, Söderqvist A, Törnkvist H. Internal fixation compared with total hip replacement for displaced femoral neck fractures in the elderly A RANDOMISED, CONTROLLED TRIAL. Journal of Bone & Joint Surgery, British Volume. 2003;85(3):380-8.
13. Blomfeldt R, Törnkvist H, Ponzer S, Söderqvist A, Tidermark J. Comparison of internal fixation with total hip replacement for displaced femoral neck fractures. The Journal of Bone & Joint Surgery. 2005;87(8):1680-8.
14. Anglen JO. Intertrochanteric osteotomy for failed internal fixation of femoral neck fracture. Clinical orthopaedics and related research. 1997;341:175-82.
15. Norouzi M. Treatment of the non:union: of the femoral neck by Valgus osteotomy. Archives of Iranian Medicine. 2005;8(2):131-4.
16. Phipps WJ. Medical-surgical nursing: health and illness perspectives: Mosby; 2003.
17. Curran D, Maravic M, Kiefer P, Tochon V, Fardellone P. Epidemiology of osteoporosis-related fractures in France: a literature review. Joint Bone Spine. 2010;77(6):546-51.
18. Adachi JD, Adami S, Gehlbach S, Anderson FA, Boonen S, Chapurlat RD, et al., editors. Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women. Mayo Clinic Proceedings; 2010: Elsevier.
19. Jørgensen C, Kehlet H, Soeballe K, Hansen TB, Laursen MB, Hansen LT, et al. Role of patient characteristics for fast-track hip and knee arthroplasty. British journal of anaesthesia. 2013:aes505.
20. Mirdad T. Fractures of the neck of femur in children: an experience at the Aseer Central Hospital, Abha, Saudi Arabia. Injury. 2002;33(9):823-7.
21. Ballmer F, Ballmer P, Baumgaertel F, Ganz R, Mast J. Pauwels osteotomy for non:union:s of the femoral neck. The Orthopedic clinics of North America. 1990;21(4):759-67.
22. Raaymakers EL, Marti RK. Non:union: of the femoral neck: possibilities and limitations of the various treatment modalities. Indian journal of orthopaedics. 2008;42(1):13.
23. Raaymakers E. Fractures of the Femoral Neck. A Review and Personal Statement. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca. 2006;73(1):45.
24. Parker MJ, Raghavan R, Gurusamy K. Incidence of fracture-healing complications after femoral neck fractures. Clinical orthopaedics and related research. 2007;458:175-9.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |