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:: Volume 7, Issue 3 (9-2018) ::
Int J Med Invest 2018, 7(3): 1-10 Back to browse issues page
Effect Of Vitamin D Supplementation With Anti-Viral Therapy On CD4 Levels In HIV-Infected Patients: Systematic Review And Meta-Analysis
Fatemeh Roozbeh , Maryam Ghajar *
Mazandaran Uinversity of Medical Sciences, Sari, Iran
Abstract:   (476 Views)
Introduction: Due to the effect of vitamin D on the immune response, There are controversial results about the effect of vitamin D supplementation on the immune system of AIDS patients. This systematic review and meta-analytical was conducted to determine the effect of vitamin D supplementation, along with antiretroviral treatment on CD4 count of HIV-infected patients. Methods: This systematic review and meta-analysis study was done with using specific keywords HIV and vitamin D and CD4 and related keywords on published articles by the end of 2017 in the some databases such as Pubmed (116 articles), Scopus (121 articles) and Web of Science (127 articles). All articles have been export to ENDNOTE and after deleting duplicate, there was 174 articles. Review selected articles by two individuals, first on the title and abstract. Clinical trial studies about vitamin D supplementation on HIV-infected patients which receiving ART were selected. Quality assessment of studies was conducted by Jadad criteria. CD4 count and viral load before and after intervention in treatment and placebo groups, age of patients and duration of intervention were extracted. Fiundings: Finally, 7 clinical trial studies with a sample size of 639 people were entered the meta-analysis. The mean age of patients in the treatment group and placebo was 27.2 and 26.5 years respectively, and mean duration of intervention was 8.3 months. The increase in CD4 after treatment was 0.73 (CI95%:-0.43 - 1.89) compared with the placebo group which was not statistically significant, but Vitamin D use in 3 studies was near one year and this change (SMD=3.56, CI95%: 1.17-5.96) was significantly in these studies. Egger's test results showed that there was no publication bias. Conclusion: The results showed that at least 10 months use of vitamin D supplementation with antiviral therapy can effectively help in increasing the CD4 level in comparison with placebo.
Keywords: Vitamin D, Antiviral treatment, CD4, AIDS, HIV
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Type of Study: Review | Subject: General
References
1. 1. GBD 2015 Eastern Mediterranean Region HIV/AIDS Collaborators. Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990-2015: findings from the Global Burden of Disease 2015 study. Int J Public Health. 2018;63(Suppl 1):123-136. 2. Fettig J, Swaminathan M, Murrill CS, Kaplan JE. Global epidemiology of HIV. Infect Dis Clin North Am. 2014; 28(3):323-37. 3. Bhatt B, Jindal H, Sk S, Malik JS, Sangwan K, Resident J. Vaccination in HIV positive adults: need to address. Hum Vaccin Immunother. 2014;10(10):3011-2. 4. Holick MF. Vitamin D Deficiency .N Engl J Med.2007;357(3):266-281 5. Prosser DE, Jones G. Enzymes involved in activation and inactivation of vitamin D. Trend Biochem Sci.2004;29(12):664-673 6. Van Den Bout-Van Den Beukel CJ, Fievez L, Michels M, Sweep FC, Hermus AR, Bosch ME, et al. Vitamin D Deficiency among HIV type 1 Infected Individuals in the Netherland: Effects of RetroViral therapy. AIDS Res Hum Retroviruses 2008;24(11):1375-1382 7. Djukic M, Onken ML, Schütze S, Redlich S, Götz A, Hanisch UK, et al. Vitamin D deficiency reduces the immune response, the phagocytosis rate and intracellular killing rate of microglial cells. Infect Immun. 2014; 82(6):2585-2594. 8. Rodriguez M, Daniels B, Gunawardene S, Robbins GK. High frequency of vitamin D deficiency in ambulatory HIV-Positive patients. AIDS Res Hum Retroviruses. 2009; 25(1):9-14. 9. Cannell JJ, Hollis BW, Zasloff M, Heaney RP. Diagnosis and Treatment of Vitamin D Deficiency. Expert Opin Pharmacother. 2008; 9(1):107-118. 10. Dao CN, Patel P, Overton ET, Rhame F, Pals SL, Johnson C, et al. Low vitamin D among HIV-infected adults: prevalence of and risk factors for low vitamin D Levels in a cohort of HIV-infected adults and comparison to prevalence among adults in the US general population. Clin Infect Dis. 2011; 52(3):396-405. 11. Lattuada E, Lanzafame M, Zoppini G, Concia E, Vento S. No influence of nevirapine on vitamin D deficiency in HIV-infected patients. AIDS Res Hum Retroviruses 2009; 25 (8):849–50. 12. Brown TT, McComsey GA. Association between initiation of antiretroviral therapy with efavirenz and decreases in 25-hydroxyvitamin D. Antivir Ther 2010; 15(3):425-9. 13. Steenhoff AP, Schall JI, Samuel J, Seme B, Marape M, Ratshaa B, et al. Vitamin D3 supplementation in Batswana children and adults with HIV: A pilot double blind randomized controlled trial. PLoS ONE. 2015;10(2). e0117123. 14. Stallings VA, Schall JI, Hediger ML, Zemel BS, Tuluc F, Dougherty KA, et al. High-dose vitamin D3 supplementation in children and young adults with HIV: A randomized, placebo-controlled trial. J Pediatr Infect Dis. 2015;34(2):e32-e40. 15. Overton ET, Chan ES, Brown TT, Tebas P, McComsey GA, Melbourne KM, et al. Vitamin D and Calcium Attenuate Bone Loss With Antiretroviral Therapy Initiation A Randomized Trial. Ann Intern Med. 2015;162(12):815-24. 16. Falasca K, Ucciferri C, Di Nicola M, Vignale F, Di Biase J, Vecchiet J. Different strategies of 25OH vitamin D supplementation in HIV-positive subjects. Int J Std Aids. 2014;25(11):785-92. 17. Kakalia S, Sochett EB, Stephens D, Assor E, Read SE, Bitnun A. Vitamin D supplementation and CD4 count in children infected with human immunodeficiency virus. J Pediatr. 2011;159(6):951-7. 18. Bang UC, Kolte L, Hitz M, Schierbeck LL, Nielsen SD, Benfield T, et al. The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV type 1-infected males: results of a clinical trial. AIDS Res Hum Retroviruses. 2013;29(4):658-64. 19. Arpadi SM, McMahon D, Abrams EJ, Bamji M, Purswani M, Engelson ES, et al. Effect of bimonthly supplementation with oral cholecalciferol on serum 25-hydroxyvitamin D concentrations in HIV-infected children and adolescents. Pediatrics. 2009;123(1):e121-6. 20. Forrester JE, Sztam KA. Micronutrients in HIV/AIDS: is there evidence to change the WHO 2003 recommendations? Am J Clin Nutr. 2011; 94(6):1683S-1689S. 21. Jiménez-Sousa MÁ, Martínez I, Medrano LM, Fernández-Rodríguez A, Resino S. Vitamin D in Human Immunodeficiency Virus Infection: Influence on Immunity and Disease. Front Immunol. 2018 Mar 12;9:458. 22. Visser ME, Durao S, Sinclair D, Irlam JH, Siegfried N. Micronutrient supplementation in adults with HIV infection. Cochrane Database Syst Rev. 2017; 5:CD003650
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Roozbeh F, Ghajar M. Effect Of Vitamin D Supplementation With Anti-Viral Therapy On CD4 Levels In HIV-Infected Patients: Systematic Review And Meta-Analysis. Int J Med Invest. 2018; 7 (3) :1-10
URL: http://intjmi.com/article-1-329-en.html


Volume 7, Issue 3 (9-2018) Back to browse issues page
International Journal of Medical Investigation
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