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Int J Med Invest 2018, 7(4): 5-14 Back to browse issues page
Effects of Low-Level Laser Therapy with Wrist Splinting on Outcome of Patients with Carpal Tunnel Syndrome; A Randomized, Double-Blind, Placebo-Controlled Trial
Shila Haghighat *, Zohre Zabihi, Saeid Khosrawi
1. Assistant Professor of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (1513 Views)
Introduction: To determine the long-term effects of low-level laser therapy (LLLT) on clinical symptoms and electrophysiological parameters of patients with mild and moderate carpal tunnel syndrome (CTS).
Methods: This randomized, double-blind, placebo-controlled trial was conducted during a 1-year period in January 2015 to January 2016 in outpatient clinics of Isfahan University of Medical Sciences. This study is registered with Iranian Clinical Trial Registry (IRCT20120716010297N5). We included 61 hands with mild and moderate CTS from both genders with an age range of 30 to 65 years. The hands were randomly assigned to receive LLLT and night wrist splint (n=31) or sham laser therapy and night wrist splint (n=30).  Symptoms severity scores (SSS), functional severity score (FSS), visual analogue scale (VAS) and nerve conductive study (NCS) parameters using electrodiagnostic equipment were evaluated based on clinical parameters (Phalen’s and Tinel tests) at 6 months after treatment.
Findings: The baseline characteristics were comparable between two study groups. The VAS, SSS, FSS, peak sensory latency and distal motor latency decreased significantly in both study group after 6 months of intervention. We found that those receiving LLLT had significantly lower VAS (p=0.001), SSS (p<0.001) and FSS (p<0.001) compared to sham laser therapy after 6 months of follow-up.  In the same way, those in LLLT group had significantly lower values of peak sensory latency compared to sham group (p<0.001). Those receiving LLLT had significantly higher decrease in mean values of VAS (p=0.032), SSS (p=0.021), FSS (p=0.002) and distal motor latency (p<0.001) when compared to those in sham group. However, the decrease in mean differences of peak sensory latency was comparable between two study groups.
Conclusion: LLLT is associated with improved pain, symptoms, function and sensory evoked potentials after 6 months in patients with mild to moderate CTS. 
Keywords: Low-Level Laser Therapy, Carpal Tunnel Syndrome (CTS), Wrist Splint, Outcome
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Type of Study: Research | Subject: General
1. 1. Aboonq MS. Pathophysiology of carpal tunnel syndrome. Neurosciences (Riyadh). 2015;20(1):4-9. 2. Newington L, Harris EC, Walker-Bone K. Carpal tunnel syndrome and work. Best Pract Res Clin Rheumatol. 2015;29(3):440-53. 3. Atroshi I, Gummesson C, Johnsson R, Ornstein E, Ranstam J, Rosén I. Prevalence of carpal tunnel syndrome in a general population. JAMA. 1999;282(2):153-8. 4. Ashworth NL. Carpal Tunnel Syndrome. Am Fam Physician. 2016;94(10):830-1. 5. Cooke ME, Duncan SFM. History of Carpal Tunnel Syndrome. In: Duncan SFM, Kakinoki R, editors. Carpal Tunnel Syndrome and Related Median Neuropathies: Challenges and Complications. Cham: Springer International Publishing; 2017. p. 7-11. 6. Evers S, Bryan AJ, Sanders TL, Gunderson T, Gelfman R, Amadio PC. Corticosteroid Injections for Carpal Tunnel Syndrome: Long-Term Follow-Up in a Population-Based Cohort. Plast Reconstr Surg. 2017;140(2):338-47. 7. Huisstede BM, Friden J, Coert JH, Hoogvliet P. Carpal tunnel syndrome: hand surgeons, hand therapists, and physical medicine and rehabilitation physicians agree on a multidisciplinary treatment guideline-results from the European HANDGUIDE Study. Arch Phys Med Rehabil. 2014;95(12):2253-63. 8. Gerritsen AA, de Krom MC, Struijs MA, Scholten RJ, de Vet HC, Bouter LM. Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials. J Neurol. 2002;249(3):272-80. 9. Golriz B, Ahmadi Bani M, Arazpour M, Bahramizadeh M, Curran S, Madani SP, et al. Comparison of the efficacy of a neutral wrist splint and a wrist splint incorporating a lumbrical unit for the treatment of patients with carpal tunnel syndrome. Prosthet Orthot Int. 2016;40(5):617-23. 10. Riasi H, Rajabpour Sanati A, Salehi F, Salehian H, Ghaemi K. Analyzing the therapeutic effects of short wrist splint in patients with carpal tunnel syndrome (CTS) under ibuprofen treatment from an EMG-NCV perspective. J Med Life. 2015;8(Spec Iss 4):154-8. 11. Bekhet AH, Ragab B, Abushouk AI, Elgebaly A, Ali OI. Efficacy of low-level laser therapy in carpal tunnel syndrome management: a systematic review and meta-analysis. Lasers Med Sci. 2017;32(6):1439-48. 12. Burger M, Kriel R, Damon A, Abel A, Bansda A, Wakens M, et al. The effectiveness of low-level laser therapy on pain, self-reported hand function, and grip strength compared to placebo or "sham" treatment for adults with carpal tunnel syndrome: A systematic review. Physiother Theory Pract. 2017;33(3):184-97. 13. Chen Y, Zhao CQ, Ye G, Liu CD, Xu WD. Low-power laser therapy for carpal tunnel syndrome: effective optical power. Neural Regen Res. 2016;11(7):1180-4. 14. Fusakul Y, Aranyavalai T, Saensri P, Thiengwittayaporn S. Low-level laser therapy with a wrist splint to treat carpal tunnel syndrome: a double-blinded randomized controlled trial. Lasers Med Sci. 2014;29(3):1279-87. 15. Lazovic M, Ilic-Stojanovic O, Kocic M, Zivkovic V, Hrkovic M, Radosavljevic N. Placebo-controlled investigation of low-level laser therapy to treat carpal tunnel syndrome. Photomed Laser Surg. 2014;32(6):336-44. 16. Irvine J, Chong SL, Amirjani N, Chan KM. Double-blind randomized controlled trial of low-level laser therapy in carpal tunnel syndrome. Muscle Nerve. 2004;30(2):182-7. 17. Tascioglu F, Degirmenci NA, Ozkan S, Mehmetoglu O. Low-level laser in the treatment of carpal tunnel syndrome: clinical, electrophysiological, and ultrasonographical evaluation. Rheumatol Int. 2012;32(2):409-15. 18. Franke TP, Koes BW, Geelen SJ, Huisstede BM. Do Patients With Carpal Tunnel Syndrome Benefit From Low-Level Laser Therapy? A Systematic Review of Randomized Controlled Trials. Arch Phys Med Rehabil. 2017. 19. Li ZJ, Wang Y, Zhang HF, Ma XL, Tian P, Huang Y. Effectiveness of low-level laser on carpal tunnel syndrome: A meta-analysis of previously reported randomized trials. Medicine (Baltimore). 2016;95(31):e4424. 20. Dincer U, Cakar E, Kiralp MZ, Kilac H, Dursun H. The effectiveness of conservative treatments of carpal tunnel syndrome: splinting, ultrasound, and low-level laser therapies. Photomed Laser Surg. 2009;27(1):119-25. 21. Rayegani SM, Bahrami MH, Eliaspour D, Raeissadat SA, Shafi Tabar Samakoosh M, Sedihgipour L, et al. The effects of low intensity laser on clinical and electrophysiological parameters of carpal tunnel syndrome. J Lasers Med Sci. 2013;4(4):182-9. 22. Raeissadat A, Soltani ZR. Study of long term effects of laser therapy versus local corticosteroid injection in patients with carpal tunnel syndrome. Journal of Lasers in Medical Sciences. 2010;1(1):24. 23. Evcik D, Kavuncu V, Cakir T, Subasi V, Yaman M. Laser therapy in the treatment of carpal tunnel syndrome: a randomized controlled trial. Photomed Laser Surg. 2007;25(1):34-9. 24. Bjordal JM. Low level laser therapy (LLLT) and World Association for Laser Therapy (WALT) dosage recommendations. Photomed Laser Surg. 2012;30(2):61-2. 25. Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA. A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother. 2003;49(2):107-16.
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Haghighat S, Zabihi Z, Khosrawi S. Effects of Low-Level Laser Therapy with Wrist Splinting on Outcome of Patients with Carpal Tunnel Syndrome; A Randomized, Double-Blind, Placebo-Controlled Trial. Int J Med Invest. 2018; 7 (4) :5-14
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Volume 7, Issue 4 (12-2018) Back to browse issues page
International Journal of Medical Investigation
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