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:: Volume 7, Issue 3 (9-2018) ::
Int J Med Invest 2018, 7(3): 77-82 Back to browse issues page
Ectopic Cushing's syndrome Of Unknown Origin: A Rare Case Report
Saied Amirkhanlou , Mohammad Mehdi Ebrahimi , Arash Rezaei Shahmirzadi *
Medical student, Student Research Committee, Golestan University of Medical Sciences, Golestan, Iran
Abstract:   (317 Views)
Background: Cushing’s syndrome is a rare disease caused by excessive secretion of cortisol by adrenal cortex (hypercortisolism). Bilateral adrenal hyperplasia due to increased secretion of adrenocorticotropic hormone (ACTH) by pituitary gland is usually known as the main cause of Cushing’s syndrome. The 5-year survival rate for patient with Cushing’s syndrome is approximately 50% unless associated with treatment. Etiologic diagnosis therefore plays an important role in prompt treatment. The purpose of this study is to inspect a Cushing’s syndrome with unknown cause. Case presentation: A 36-year-old married man with complaint of periorbital and upper trunk swelling (with no buffalo hump) and lower extremity weakness presented to doctor’s clinic. He also had a one-year history of blurred vision, hypertension, facial and periorbital edema and difficulty getting up from a sitting. After physical examinations and laboratory testing, diagnosis of Cushing’s disease with unknown cause was made and surgical removal of both adrenal glands was suggested. He underwent bilateral adrenalectomy in two separate operations and his symptoms gradually reduced during the next months. Conclusion: According to this study and other same case report studies conducted, surgical removal of adrenal gland is the most effective treatment if the patient does not respond to medication. Even if the cause of Cushing’s disease is not known, like the case mentioned.
Keywords: Cushing's syndrome, Adrenocorticotropic hormone, hypercortisolism
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Type of Study: case report | Subject: General
References
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Amirkhanlou S, Ebrahimi M M, Rezaei Shahmirzadi A. Ectopic Cushing's syndrome Of Unknown Origin: A Rare Case Report. Int J Med Invest. 2018; 7 (3) :77-82
URL: http://intjmi.com/article-1-340-en.html


Volume 7, Issue 3 (9-2018) Back to browse issues page
International Journal of Medical Investigation
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