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:: Volume 4, Issue 3 (September 2015) ::
Int J Med Invest 2015, 4(3): 299-305 Back to browse issues page
Role of maternal serum inhibin A and insulin – like growth factor 1 levels as predictors of fetal outcome in high risk pregnancies.
Salam Sushila , Binita Goswami * , Anju Jain , M K Narula , Abha Singh
Associate Professor, Department of Biochemistry, Lady Hardinge Medical College & associated Smt Sucheta Kriplani Hospital, New Delhi, INDIA
Abstract:   (8876 Views)
Abstract Background: Timely prediction of adverse pregnancy and perinatal outcome has been the endeavor of clinicians since a long time. Identification and validation of a serum based biomarker is the need of the hour and many tentative molecules have been studied with variable results. Two such molecules are inhibins and insulin like growth factors. This study was planned to assess the utility of inhibin A and IGF-1 as predictors of adverse pregnancy and fetal outcomes. Methods: The study population comprised of all pregnant women presenting to the ante natal clinic in SSK hospital between gestation periods of 24-28 weeks fulfilling the inclusion criteria. The criteria adopted for inclusion in the study included primi-gravida with singleton pregnancy or multi-gravida with high risk factors in the previous pregnancy such as gestational hypertension, preeclampsia, eclampsia, placental abruption, intrauterine growth retardation, intrauterine fetal demise, preterm delivery and early pregnancy loss. Results: The mean levels of inhibin A were significantly higher in women with overall adverse pregnancy outcome such as preeclampsia, gestational hypertension, and preterm delivery as compared to the normal counterparts. No significant difference in the level of IGF-1 was observed with various adverse outcomes. Inhibin A at the cutoff of > 443pg/ml was found to be reliable marker of preeclampsia and preterm delivery. Conclusion: We may hypothesize from our findings that second trimester inhibin A levels may be further evaluated through large prospective studies as an reliable biomarker of adverse pregnancy outcome.
Keywords: Preeclampsia, IGF-1, Inhibin A, SGA
Full-Text [PDF 380 kb]   (2309 Downloads)    
Type of Study: Research | Subject: General
References
1. References 1. Viler K. Eclampsia and pre-eclampsia: a health problem for 2000 years. In: Critchley H, Maclean A, Poston L,editors. Preeclampsia. London, UK: RCOG press;2003:189-207 2. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005;308(5728):1592-4. 3. Muttukrishna S, George L, Fowler PA, Groome NP, Knight PG. measurement of serum concentrations of inhibin A during human pregnancy. Clin Endocrinol 1995;2:391-97. 4. Muttukrishna S, North RA, Morris J, Schellenberg JC, Taylor RS, et al. serum inhibin A abd activin A are elevated prior to onset of preeclampsia. Hum Reprod 2000;15(7):1640-5. 5. Giudice LC, Martina NA, Crystal RA, et al. insulin like growth factor binding protein-1 at the maternal-fetal interface and insulin – like growth factor –I, insulin- like growth factor –II, and insulin-like growth factor binding protein-I in the circulation of women with severe preeclampsia. Am J Obstet Gynecol 1997;176:751-58. 6. Aquilina J, Barnett A, Thompson O, Harrington K. comprehensive analysis of uterine artery flow velovity waveforms for the prediction of preeclampsia. Ultrasound Obstet Gynecol 2000;16: 163-170. 7. Ay E, Kavak ZN, Elter K, Gokaslan H, Pekin T. Screening for preeclampsia by using maternal serum inhibin A, activin A, human chorionic gonadotropin, unconjugated estriol, and alpha fetoprotein levels and uterine artery Doppler in the second trimester of pregnancy. Aust N Z J Obstet Gynecol 2005;45(4):283-8. 8. Dane B, Batmaz G, Kilavuz K, Rustemoglu Y, Guler H, Dane C. analysis of the relationship between maternal second trimester AFP, HCG, estriol levels and uterine artery Doppler findings in the prediction of pregnancy complications. Perinatal Journal 2012;20(1):24-29. 9. Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007;49(4):818-24. 10. Lockwood CJ. Predicting premature delivery- not easy task. N Engl J Med 2002;364(4):282-4. 11. Aitken DA, Wallace EM, Crosley JA, Swanston IA, van Pareren Y, van Maarle M et al. Dimeric Inhibin A as a marker for Down’s syndrome in early pregnancy. N Engl J Med 1996;334(19):1231-6. 12. Dugoff L, Hobbins JC, Malone FD, Vidaver J, Sullivan L, Canick JA et al. FASTER Trial Research Consortium. Quad screen as apredictor of adverse pregnancy outcome. Obstet Gynecol 2005;106(2):260-7. 13. Spencer K, Yu CK, Savvidou M, Papgeorghiou AT, Nocolaides KH. Prediction of preeclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-assocaited plasma protein-A,free beta human chorionic gonadotropin, activin A and inhibin A at 22+0 to 24+6weeks gestation. Ultrasound Obstet Gynecol 2006;27(6):658-63. 14. Florio P, Ciarmela P, Luisi S, Palumbo MA, Lambert- Messerlian G, Severi FM et al. Pre eclampsia with fetal growth retardation: placental and serum activin a and inhibin A levels. Gynecol endocrinol 2002;16(5):365-72. 15. Fitzgerald B, Levytska K, Kingdom J, Walker M, Baczyk D, Keating S. Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin A. Placenta 2011;32(4):339-45. 16. Dayal M , Gupta P , Varma M , Ghosh UK , Bhargava A. Role of Second Trimester Maternal Serum Markers as Predictor of Preeclampsia. J Obstet and Gynecol Ind. 2011 pg 38 – 41. 17. Stewart CEH, Rotwein P. Growth, differentiation, and survival: multiple physiological functions for insulin like growth factors./ Physiol Rev 1996;76:1005-1026. 18. Hernandez- Valencia M, Zarate A, Ochoa R, Fonseca ME, Amato D, De Jesus Ortiz M. Insulin like growth factor-1, epidermal growth factor and transforming growth factor beta expression and their association with intrauterine fetal growth retardation such as development during huma pregnancy. Diabetes Obes Metab 2001;3(6):457-62. 19. Giudice LC, Martina NA, Crystal RA, et al. Insulin like growth factor binding protein-1 at the maternal- fetal interface and insulin like growth factor-1, insulin like growth factor II and insulin like growth factor binding protein-I in the circulation of women with severe preeclampsia. Am J Obstet Gynecol 1997;176:751-8. 20. Halhali A, Tovar AR, Torres N, Bourges H, Garabedian M, Larrea F. Preeclampsia is associated with low circulating levels of insulin –like growth factor-1 and 1,25 dihydroxyvitamin D in maternal and umbilical cord compartments. J Clin Endocrinol Metab 2000;85:1828-33. 21. Shang LX, Wang J, Zhang LJ, Gao H, Qu DY, Wang JH. Relationship between changes of insulin like growth factor-1 and insulin like growth factor binding protein -1 in maternal serum and placenta and pathogenesis of hypertensive disorder complicating pregnancy. Zhonghua Fu Chan Ke Za Zhi 2005;40(8):255-9. 22. Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E et al. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: Is there a relationship with fetal growth and neonatal anthropometry? Clin Chem 2008;54(#):550-8. 23. Lindsay RS, Westgate A, Beattie J, Pattison NS, Gamble G, Mildenhall LFJ et al. Inverse changes in fetal insulin-like growth factor (IGF)-1 and IGF binding protein-1 in association with higher birth weight in maternal diabetes. Clin Endocrinol 2007;66(3):322-328.
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Sushila S, Goswami B, Jain A, Narula M K, Singh A. Role of maternal serum inhibin A and insulin – like growth factor 1 levels as predictors of fetal outcome in high risk pregnancies.. Int J Med Invest 2015; 4 (3) :299-305
URL: http://intjmi.com/article-1-176-en.html


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Volume 4, Issue 3 (September 2015) Back to browse issues page
International Journal of Medical Investigation
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