|
Evaluation of the effects of anticoagulant drugs on the rate of bleeding of oral surgeries and warfarin alternatives
|
Amirhosein Pakravan   , Tahmine Bamdadian , Pouya Akbari , Arash Alimirzaei , Ali Samiei , Mahdi Babaei Hatkehloui , Mahdi Taghian * |
| Department of oral and maxillofacial surgery, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran |
|
|
Abstract: (10292 Views) |
| Introduction: Today, with advances in the treatment of cardiovascular patients such as intravascular stents, cardiac valves and intracavitary pacemakers and cardiac transplantation, many cardiovascular patients should use anticoagulants such as warfarin, aspirin, Plavix and Sosix, Ticlopidine and other drugs. The aim of this study was to investigate the effects of coagulation drugs on the rate of bleeding of oral surgeries and warfarin alternative. Methods: For access to studies on anticoagulant drugs and their effect on the bleeding of oral surgery in heart patients, the PUBMED, MEDLINE, MAGIRAN, SID, ELMNET and GOOGLE databases have been used since 1998 to 2015. Keywords include oral surgery, anticoagulants, warfarin, dentistry and bleeding. Findings: In the investigations done on the studied articles, it seems that patients with anticoagulant drugs that are supposed to undergo minor dental surgeries do not require discontinuation, dose reduction, or even control of coagulation factors and bleeding can only be controlled by local dental procedures such as suturing, mouthwash, gel sponge. And the risk of severe complications in case of warfarin interruption and thrombosis is more than uncontrolled bleeding from the teeth. There is also no need for alternative warfarin medicines. Conclusion: The hazard of severe complications in case of warfarin interruption and thrombosis is more than uncontrolled hemorrhage from the teeth. There is also no need for alternative warfarin treatments. |
|
| Keywords: Oral Surgery, Anticoagulants, Warfarin, Dentistry, Bleeding |
|
|
Full-Text [PDF 345 kb]
(4095 Downloads)
|
|
Type of Study: Review |
Subject:
General
|
|
|
|
|
|
|
| References |
|
1. 1. Sacco R, Sacco M, Carpenedo M, Mannucci PM. Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different intensity targets. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2007 Jul;104(1):e18-21.
2. Roser SM, Rosenbloom B. Continued anticoagulation in oral surgery procedures. Oral Surg Oral Med Oral Pathol. 1975 Oct;40(4):448-57.
3. Fonseca RJ. Oral and maxillofacial surgery. 1st ed. Philadelphia: W.B. Saunders Co; 2000.
4. O'Reilly RA, Aggeler PM. Studies on coumarin anticoagulant drugs: Initiation of warfarin therapy without a loading dose. Circulation 1968; 38(1): 169-77.
5. Haraji A, Zare Mahmood Abadi, Khadem Hosseini A. Dental extractions in patients maintained on oral anticoagulant therapy: comparison of International Normalized Ratio (INR) value with occurrence of postoperative bleeding. Dent J Mashhad Univ Medi Scie 2005; 29: 45-50.
6. Bonow RO, Carabello B, de Leon AC, Edmunds LH Jr, Fedderly BJ, Freed MD,et al.ACC/AHA guidelines for the management of patients with valvular heart disease. Executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease). J Heart Valve Dis. 1998 Nov;7(6):672-707.
7. Hirsh J, Fuster V, Ansell J, Halperin JL .American Heart Association/American College of Cardiology foundation guide to warfarin therapy. Circulation. 2003 Apr 1;107(12):1692-711.
8. Al-Harkan AM, Al-Ayoub GA .Should antiplatelet and anticoagulant medications be discontinued before minor oral surgery procedures?. J Can Dent Assoc. 2012;78:c24.
9. Girotra C, Padhye M, Mandlik G, Dabir M, Gite M, Dhonnar R, Pandhi V ,et al.Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study. Int J Oral Maxillofac Surg. 2014 Jan;43(1):99-106.
10. Napeñas JJ, Hong CH, Brennan MT, Furney SL, Fox PC, Lockhart PB. The frequency of bleeding complications after invasive dental treatment in patients receiving single and dual antiplatelet therapy. J Am Dent Assoc. 2009 Jun;140(6):690-5.
11. Ciske D, Robinson E, Ford M. Periprocedural and Regional Anesthesia Management with Antithrombotic Therapy – Adult – Inpatient and Ambulatory– Clinical Practice Guideline. Wisconsin univ
12. Pototski M1, Amenábar JM. Dental management of patients receiving anticoagulation or antiplatelet treatment. J Oral Sci. 2007 Dec;49(4):253-8.
13. Wahl MJ, Pinto A, Kilham J, Lalla RV. Dental surgery in anticoagulated patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Feb;119(2):136-57.
14. Alexander R, Ferretti AC, Sorensen JR. Stop the nonsense not the anticoagulants: a matter of life and death. N Y State Dent J. 2002 Nov;68(9):24-6.
15. Zhang K, Yong C, Berger J. Administrative claims analysis of the relationship between warfarin use and risk of hemorrhage including drug-drug and drug-disease interactions. J Manag Care Pharm 2006; 12: 640-8.
16. Abdulsattar Y, Bhambri R, Nogid A. Rivaroxaban (xarelto) for the prevention of thromboembolic disease: an inside look at the oral direct factor xa inhibitor. P T. 2009 May;34(5):238-44.
17. Lillis T, Ziakas A, Koskinas K, Tsirlis A, Giannoglou G. Safety of dental extractions during uninterrupted single or dual antiplatelet treatment. Am J Cardiol. 2011 Oct 1;108(7):964-7.
18. Peymani Mojaver A, Soltani M, Bakhshi H. Effect of Gelatin Sponge and Tranexamic Acid M.rinses on Prevention of Bleeding after Dental Extraction in Patients Taking Warfarin. J Mash Dent Sch 2011; 35(1): 17-22.
19. Morimoto Y, Niwa H, Minematsu K. Hemostatic management of toothextractions in patients on oral antithrombotic therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec;108(6):889-96.
20. Salam S, Yusuf H, Milosevic A. Bleeding after dental extractions in patients taking warfarin. Br J Oral Maxillofac Surg. 2007 Sep;45(6):463-6.
21. Al-Belasy FA, Amer MZ.Hemostatic effect of n-butyl-2-cyanoacrylate (histoacryl) glue in warfarin-treated patients undergoing oral surgery. Journal of oral and maxillofacial surgery. J Oral Maxillofac Surg. 2003 Dec;61(12):1405-9.
22. Evans IL, Sayers MS, Gibbons AJ, Price G, Snooks H, Sugar AW. Can warfarin be continued during dental extraction? Results of a randomized controlled trial. Br J Oral Maxillofac Surg. 2002 Jun;40(3):248-52.
23. Campbell JH, Alvarado F, Murray RA.Anticoagulation and minor oral surgery: should the anticoagulation regimen be altered?. J Oral Maxillofac Surg. 2000 Feb;58(2):131-5.
24. Pooria A, Teimouri H, Cheraghi M, Ahmadi BB, Namdari M, Alipoor R. Comparison of postoperative bleeding in patients undergoing coronary artery bypass surgery in two groups taking aspirin and aspirin plus CLS clopidogrel. Middle East Journal of Family Medicine. 2017 Oct 1;7(10):17.
25. Blinder D, Manor Y, Martinowitz U, Taicher S, Hashomer T. Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Aug;88(2):137-40.
|
|
| Add your comments about this article |
|
|
|
|
Pakravan A, Bamdadian T, Akbari P, Alimirzaei A, Samiei A, Babaei Hatkehloui M et al . Evaluation of the effects of anticoagulant drugs on the rate of bleeding of oral surgeries and warfarin alternatives. Int J Med Invest 2018; 7 (1) :1-6 URL: http://intjmi.com/article-1-295-en.html
|
