Zn Status in Gastroenteritis Children under Five Years Old

Aliasgharpour, Mehri

[Home ] [Archive]

International Journal of Medical Investigation

Main Menu

Home

Journal Information

Articles archive

For Authors

For Reviewers

Registration

Contact us

Site Facilities

Editorial Board

Search in website

Receive site information

Volume 4, Issue 1 (march 2015)

Int J Med Invest 2015, 4(1): 180-182

Back to browse issues page

Zn Status in Gastroenteritis Children under Five Years Old

Mehri Aliasgharpour ^*

Clinical Biochemistry Faculty Member at Reference Health Laboratory Research Center ,Ministry of Health & Medical Education, Tehran, Iran.

Abstract: (9215 Views)

Abstract Background. Acute gastroenteritis is one of the most prevalent infectious illnesses in childhood and frequently associated with severe zinc deficiency. The objective of present study was to determine zinc status in 32 gastroenteritis girls and boys under 5 years old not on Zn supplementation at Reference health laboratory, Tehran-Iran. Materials &Method. Out of 32 gastroenteritis children six excluded and fasting serum samples of n=26 (10=girls & 16=boys) were collected. For analysis a Varian Spectra Flame Atomic Absorption was used. Results. Out of10 girls and 16 boys serum samples, [6(60%), 95%CL(38% - 60%) ] and [(11(68%), 95%CL (53% - 65%) ] had zinc level less than reference interval range (70-120 μg/dL). Results of Pearson correlation indicated significant correlation between Zn and age at p<0.05. Conclusion: The author concludes serum Zn determination is an important factor in gastroenteritis children under five years old. Although in developing countries, the role of zinc during acute diarrhea in children assess further future studies, conducting educational based programs could be useful to increase the community information on the impact of zinc during gastroenteritis and emphasize on the WHO recommendation , replacing 20 mg of elemental zinc per day for children above 6 months , to shorten the duration of acute gastroenteritis .

Keywords: Zinc- Gastroenteritis- Flame Atomic Absorption- Pearson Product Correlation

Full-Text [PDF 241 kb] (2605 Downloads)

Type of Study: Research | Subject: General

References

1. 1.Geneva: WHO; 2006. Implementing the new recommendations on the clinical management of diarrhea-Guidelines for policy makers and program managers. 2.Brown KH. Peerson JM. Baker SK. Hess SY. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull.2009;30(1):S12-40. 3.USAID Micronutrients Program. Zinc supplementation for the treatment of diarrhea. Moving from research to practice. Arlington, VA: USAID Micronutrients Program, Available from: www.zinc.org/case studies documents/zinc advocacy USAID.pdf.Accessed 2013 . 4.Strange GR. Ahrens WR. Lelyveld S. Schafermeyer RW. Pediatric emergency medicine: a comprehensive study guide.2nd ed. Toronto, ON: McGraw Hill;2002.pp347-52. 5.Berni Canani R, Buccigrossi V, Passariello A. Mechanisms of action of zinc in acute diarrhea. Curr Opin Gastroenterol. 2011 ;27(1):8-12. 6.Smith JC, Jr. Butrimovitz GP, Purdy WC. Direct measurement of zinc by atomic absorption spectroscopy. Clin Chem. 1979; 25: 1487-1479. 7.Milne D B. Trace elements. In: Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry 3rd ed. 1999. Philadelphia, W.B. Sanders Co, pp1037-1041. 8.Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ. 2003;81:197–204. 9. Black RE, Morris SS, Bryce J. Where and why are 10 million children dying every year? Lancet. 2003;361:2226–33. 10.Unicef/WHO. Diarrhea: why children are dying and what can be done. New York: Unicef ; 2009. 11.Fische walker CL. Black RE. Zinc for the treatment of diarrhea: effect on diarrhea morbidity, mortality , and incidence of future episodes. Inter J Epid.2010;39(suppl1:163-i69). 12. WHO / UNICEF Joint Statement - Clinical management of acute diarrhea. WHO / FCH / CAH / 04.7. 2004 . 13.Scrimgeour AG, Lukaski HC. Zinc and diarrheal disease: Current status and future perspectives. Curr Opin Clin Nutr Metab Care. 2008;11:711–7. 14.Chaitali Bajait and Vijay Thawani . Role of zinc in pediatric diarrhea. Indian J Pharmacol. 2011;43(3):232-5. 15.Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLOSONE. 2010; 5:e10386. 16.Bhutta ZA. Bird SM. Black RE, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. American J Clin Nut 2000;72(6):1516-1522. 17.Zoo TT. Mou J. Zhan X. Zinc supplementation in acute diarrhea . Indian J pedia.2014; DOI 10.1007/s12098-014-1504-6. 18.Medicines used in diarrhea. WHO Model Formulary of Children. 2010. [Cited on 2012 Sep 30].p.369.Availablefrom:http://www.who.int/selection_medicines/list/wmfc_2010.pdf .

Add your comments about this article

Mendeley

Zotero

RefWorks

Aliasgharpour M. Zn Status in Gastroenteritis Children under Five Years Old. Int J Med Invest 2015; 4 (1) :180-182
URL: http://intjmi.com/article-1-98-en.html

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Volume 4, Issue 1 (march 2015)

Back to browse issues page

Persian site map - English site map - Created in 0.04 seconds with 37 queries by YEKTAWEB 4660