Journal of Emergency Health Care
Formerly known as: International Journal of Medical Investigation
Volume 4, Issue 2 (June 2015)
J Emerg Health Care 2015, 4(2): 241-244 |
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Murjanatu A A, Yusuf Musa K, Ibrahim G, Garba Magaji M. Toxicity and analgesic studies of leaf methanolic extract of Maytenus senegalensis (Lam.) Exell (Celastraceae). J Emerg Health Care 2015; 4 (2) :241-244
URL: http://intjmi.com/article-1-133-en.html
URL: http://intjmi.com/article-1-133-en.html
Student, Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria
Abstract: (10509 Views)
Objective This study was conducted to investigate the toxicity and analgesic effects of the leaf methanolic extract of Maytenus senegalensis (Lam.) Exell. Methods Acute toxicity was investigated via intraperitoneal route using mice and rats, analgesic activity was investigated using two models acetic acid-induced writhing in mice and formalin induced pain in rats. Results The extract was determined to have LD (50) of 1264.91 mg/kg in both mice and rats. It significantly (0.001) inhibited acetic acid-induced writhes in mice at all doses administered (75, 150 and 300 mg/kg) in a dose dependent manner and significantly (0.01) inhibited formalin induced pain in rats, in a non-dose dependent manner. The inhibitory effect observed was higher in the extract compared to the standard used (piroxicam). Conclusion The results obtained suggested the extract to be relatively toxic in both mice and rats with a dose dependent anti-nociceptive activity.
Keywords: Toxicity, analgesic, methanolic extract, Maytenus senegalensis, Celastraceae, acetic acid-induced writhing, formalin induced pain.
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