Journal of Emergency Health Care
Formerly known as: International Journal of Medical Investigation
Volume 4, Issue 3 (September 2015)
J Emerg Health Care 2015, 4(3): 329-332 |
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kafaween H M, Nahar L A, Gsous R, Alsakarneh D, Gsous G, Jreisat D. Biological features of breast carcinoma in postmenopausal women. J Emerg Health Care 2015; 4 (3) :329-332
URL: http://intjmi.com/article-1-171-en.html
URL: http://intjmi.com/article-1-171-en.html
Resident of General Surgery , King Hussein Medical Center, Jordan
Abstract: (9359 Views)
Abstract Background: Breast carcinoma is the most common cancer in females , its incidence increase with age . The aim of this study is to analyses the biological features of breast carcinoma in postmenopausal women . Methods: Our study included 68 postmenopausal patients who underwent modified radical mastectomy in King Hussein Medical Center during the period between January 2012 and December 2014. We divided our patients into two groups : the first group was 46 Young postmenopausal patients ( YPM ) their ages from 50 to 64 years. The second group consisted of 22 elderly postmenopausal patients ( EPM ) who were 65 years of age and above . Results: Both age groups ( YPM and EPM ) had the same range of tumor size which is 2 cm and above.Tumor size was found in 80 % and 81 % respectively . YPM patients were found to have greater lymph node involvement 76 % in comparison to EPM which was 63 % . They also showed that the incidence of peritumor vascular invasion in YPM is 60 % while in the EPM patients is 50 %.Both age groups showed similar Estrogen and Progesterone receptor expression 80 % and 77 % respectively . Conclusion: Although both groups showed almost the same range of tumor size , older patients were found to have tumors with more favorable biologic characteristics in comparison to younger age group in regard to lymph node involvement and peritumor vascular invasion . Tumor responsiveness to hormonal therapy was similar in both groups .
References
1. 1-Brunicardi Charles: The Breast. Schwartz s Principles of Surgery, 9th Ed. Chapter 17, 797-913.
2- Dixon Michael: ABC of Breast Diseases. 4th Ed.
3-Margie Glissmeyer : Reviewing prognostic factors in breast cancer management , JAAPA•MAY 2007 • 20(5) •www.jaapa.com
4-Colditz GA, Bohlke K: Priorities for the primary prevention of breast cancer .CA Cancer J Clin 2014, 64:186-194.
5-Evans DG , Ingham S , Dawe S , Roberts L , Lalloo F , Brentnall AR , Stavrinos P , Howell A : Breast cancer risk assessment in 8,824 women attending a family history evaluation and screening programme .Fam Cancer 2014, 13:189-196.
6-Anthony Howell: Risk determination and prevention of breast cancer, Breast Cancer Research 2014, 16:446.
7-Yuko Kijima: Number of axillary lymph node metastases determined by preoperative ultrasound is related to prognosis in patients with breast cancer. Cancers 2010, 2, 20-31.
8- Wanqing Chen: predictors of axillary lymph node involvement in screen-detected breast cancer. 2004.
9-Cuzick J , Sestak I , Forbes JF , Dowsett M , Knox J , Cawthorn S , Saunders C , Roche N , Mansel RE , von Minckwitz G , Bonanni B , Palva T , Howell A : IBIS-II investigators: Anastrozole for prevention of breast cancer in high-risk post-menopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial .
Lancet 2014 , 383:1041-1048 .
10-Huo CW , Chew GL , Britt KL , Ingman WV , Henderson MA , Hopper JL , Thompson EW : Mammographic density-a review on the current understanding of its association with breast cancer .
Breast Cancer Res Treat 2014 , 144:479-502.
11-Karla unger-saldana: challenges to the early diagnosis and treatment of breast cancer in developing countries. World J Clin Oncol. 2014 Aug 10; 5(3): 465–477 .
12-Ruddy KJ, Gelber S, Tamimi RM, Come SE, Winer EP: Breast Cancer Presentation And Diagnostic delays in young women. Epub 2013 Nov , 2014 Jan 1;120(1):20-5.
13- Magnus Løberg, Mette Lousdal, Michael Bretthaue.: Benefits and harms of mammography screening. Breast Cancer Research 2015 , 17:63 .
14- De Abreu FB, Schwartz GN, Wells WA: Personalized therapy for breast cancer. Clin Genet. 2014 Jul ; 86(1):62-7 .
15-Angela Toss, Massimo Cristofanilli: Molecular characterization and targeted therapeutic approaches in breast cancer. Breast Cancer Research 2015 , 17:60.
16-Secreto G., Micheli A.: Testosterone and biological characteristics of breast cancers in postmenopausal women. Cancer Epidemiological Biomarkers Prev. 2009 Nov; 18(11):2942-8.
17- Mara A. Schonberg : Breast Cancer among the Oldest Old: Tumor Characteristics, Treatment Choices, and Survival, 2010 by American Society of Clinical Oncology.
18-Hans Wildiers : Relationship between Age and Axillary Lymph Node Involvement in Women with Breast Cancer. 2009 by American Society of Clinical Oncology.
19-Sofi GN , Nadeem R : Estrogen receptor and progesterone receptor status in breast cancer in relation to age, histological grade, size of lesion and lymph node involvement. Asian Pac J Cancer Prev. 2012; 13(10): 5047-52.
20-Roberto Gennari: Breast carcinoma in elderly women, 2004 American Cancer Society.
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