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COMPARISON OF SALIVARY IGA, TEAR IGA AND SERUM IGE IN PATIENTS SUFFERING FROM CHRONIC RHINOSINUSITIS
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Seyyed Abbas Hashemi   , Saeid Abediankenari * , Seyyed Madani , Mohammad Akbari |
| Microbiology and Immunology department, Faculty of Medicine, Mazandaran university of medical sciences, Sari IRAN |
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Abstract: (9946 Views) |
| Objective Chronic rhinosinusitis is one of the most common inflammatory diseases around the world which imposes two percent of the world population. Studying the impact of chronic inflammation on immunoglobulin production is a subject of different investigations. This study conducted to evaluate the effect of chronic inflammation on secretory immunoglobulin production and allergic reaction. Therefore, in the current research, we compared salivary IgA, tear IgA and serum total IgE levels of patients suffered from chronic rhinosinusitis with normal subjects to reveal the up regulation of these immunoglobulins in chronically inflamed mucosa.
Patients and Method we monitored immunoglobulins levels of 28 participants including 14 patients with chronic rhinosinusitis and 14 normal control which assayed by Elisa for total IgE and direct immunoenzymatic determination for salivary IgA and tear IgA.
Result there were no significant changes in these immunoglobulin levels as compared to controls. P value of salivary IgA was 0.963, for tear IgA, it was P=0.862 and for serum IgE became P=0.068.
Conclusion Our study indicated that allergic reaction and mucosal immunity mediated by salivary, lacrimal IgA and serum IgE didn’t play an important role in chronic inflammation. |
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| Keywords: Rhinosinusitis, salivary IgA, tear IgA, total IgE |
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Full-Text [PDF 470 kb]
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Type of Study: Research |
Subject:
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