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:: Volume 8, Issue 3 (9-2019) ::
Int J Med Invest 2019, 8(3): 21-28 Back to browse issues page
Interaction between Gut Microbiota Dysbiosis and Multiple Sclerosis
Shima Mehrabadi *
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (1345 Views)
Gut microbiota and also probiotics have a lot of interaction with immune system and can effect on immune homeostasis. Any changes in the level of gut microbiota or food probiotics can change immune system functions. Some recent studies indicated that disruption in level of the microbes can induce releasing of many pro-inflammatory factors and cause extensive inflammation in CNS. Unfortunately, the mechanisms of this process is not understood well and limited studies were done for detecting the relationship between gut microbiota and probiotics with neurological disorders associated with neuroinflammation. In this review, we gathered recent researches about this relationship to have a comprehensive look to effect of gut microbiota and diet probiotics in neuroinflammatory disorders and Multiple sclerosis as an important neuroinflammation disease.
Keywords: Gut microbiota, Multiple sclerosis, Neuroinflammation, Probiotic
Full-Text [PDF 436 kb]   (304 Downloads)    
Type of Study: Research | Subject: General
1. 1. Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, et al. Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences. 2011;108(7):3047-52. 2. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature reviews neuroscience. 2012;13(10):701. 3. Stilling RM, Dinan TG, Cryan JF. Microbial genes, brain & behaviour–epigenetic regulation of the gut–brain axis. Genes, Brain and Behavior. 2014;13(1):69-86. 4. Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, et al. Host-gut microbiota metabolic interactions. Science. 2012;336(6086):1262-7. 5. Catanzaro R, Anzalone M, Calabrese F, Milazzo M, Capuana M, Italia A, et al. The gut microbiota and its correlations with the central nervous system disorders. Panminerva medica. 2015;57(3):127-43. 6. Forsythe P, Bienenstock J, Kunze WA. Vagal pathways for microbiome-brain-gut axis communication. Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease: Springer; 2014. p. 115-33. 7. Bercik P, Collins S, Verdu E. Microbes and the gut‐brain axis. Neurogastroenterology & Motility. 2012;24(5):405-13. 8. Modi SR, Collins JJ, Relman DA. Antibiotics and the gut microbiota. The Journal of clinical investigation. 2014;124(10):4212-8. 9. Claesson MJ, Jeffery IB, Conde S, Power SE, O’connor EM, Cusack S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488(7410):178. 10. Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell. 2016;167(6):1469-80. e12. 11. Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke. Journal of Neuroscience. 2016;36(28):7428-40. 12. Butel M-J. Probiotics, gut microbiota and health. Médecine et maladies infectieuses. 2014;44(1):1-8. 13. De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences. 2010;107(33):14691-6. 14. Frazier TH, DiBaise JK, McClain CJ. Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. Journal of Parenteral and Enteral Nutrition. 2011;35(5_suppl):14S-20S. 15. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke J-D, Serino M, et al. Intestinal permeability–a new target for disease prevention and therapy. BMC gastroenterology. 2014;14(1):189. 16. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmunity reviews. 2015;14(6):479-89. 17. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009;58(8):1091-103. 18. de La Serre CB, Ellis CL, Lee J, Hartman AL, Rutledge JC, Raybould HE. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2010;299(2):G440-G8. 19. Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nature Reviews Immunology. 2016;16(6):341. 20. Westfall S, Lomis N, Kahouli I, Dia SY, Singh SP, Prakash S. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cellular and Molecular Life Sciences. 2017;74(20):3769-87. 21. Stephenson J, Nutma E, van der Valk P, Amor S. Inflammation in CNS neurodegenerative diseases. Immunology. 2018;154(2):204-19. 22. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. The Lancet. 1999;353(9165):1649-52. 23. Srodulski S, Sharma S, Bachstetter AB, Brelsfoard JM, Pascual C, Xie XS, et al. Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Molecular neurodegeneration. 2014;9(1):30. 24. Vuong B, Odero G, Rozbacher S, Stevenson M, Kereliuk SM, Pereira TJ, et al. Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring. Journal of neuroinflammation. 2017;14(1):80. 25. Elahi M, Hasan Z, Motoi Y, Matsumoto S-E, Ishiguro K, Hattori N. Region-specific vulnerability to oxidative stress, neuroinflammation, and tau hyperphosphorylation in experimental diabetes mellitus mice. Journal of Alzheimer's Disease. 2016;51(4):1209-24. 26. Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American Journal of Physiology-Endocrinology and Metabolism. 2009;296(5):E1003-E12. 27. Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, et al. High-fat diet induces apoptosis of hypothalamic neurons. PloS one. 2009;4(4):e5045. 28. Lechan RM, Toni R. Functional anatomy of the hypothalamus and pituitary. Endotext [Internet]: MDText. com, Inc.; 2016. 29. Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nature neuroscience. 2017;20(2):145. 30. Maynard CL, Elson CO, Hatton RD, Weaver CT. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012;489(7415):231. 31. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011;474(7351):327. 32. Cerf-Bensussan N, Gaboriau-Routhiau V. The immune system and the gut microbiota: friends or foes? Nature Reviews Immunology. 2010;10(10):735. 33. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nature reviews immunology. 2009;9(5):313. 34. Achiron A, Gurevich M. Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis. Autoimmunity reviews. 2006;5(8):517-22. 35. Bhargava P, Mowry EM. Gut microbiome and multiple sclerosis. Current neurology and neuroscience reports. 2014;14(10):492. 36. Mielcarz DW, Kasper LH. The gut microbiome in multiple sclerosis. Current treatment options in neurology. 2015;17(4):18. 37. Wu H-J, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut microbes. 2012;3(1):4-14. 38. Koch MW, Metz LM, Agrawal SM, Yong VW. Environmental factors and their regulation of immunity in multiple sclerosis. Journal of the neurological sciences. 2013;324(1-2):10-6. 39. Jangi S, Gandhi R, Cox LM, Li N, Von Glehn F, Yan R, et al. Alterations of the human gut microbiome in multiple sclerosis. Nature communications. 2016;7:12015. 40. Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, et al. Gut microbiota composition and relapse risk in pediatric MS: a pilot study. Journal of the neurological sciences. 2016;363:153-7. 41. Kouchaki E, Tamtaji OR, Salami M, Bahmani F, Kakhaki RD, Akbari E, et al. Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial. Clinical nutrition. 2017;36(5):1245-9. 42. Calvo-Barreiro L, Eixarch H, Montalban X, Espejo C. Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis. Autoimmunity Reviews. 2018 2018/02/01/;17(2):165-74. 43. Kouchaki E, Tamtaji OR, Salami M, Bahmani F, Daneshvar Kakhaki R, Akbari E, et al. Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled trial. Clinical Nutrition. 2017 2017/10/01/;36(5):1245-9. 44. Kwon H-K, Kim G-C, Kim Y, Hwang W, Jash A, Sahoo A, et al. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clinical immunology. 2013;146(3):217-27. 45. Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, et al. Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls. BMC neurology. 2016;16(1):182. 46. De Cruz P, Kang S, Wagner J, Buckley M, Sim WH, Prideaux L, et al. Association between specific mucosa‐associated microbiota in Crohn's disease at the time of resection and subsequent disease recurrence: A pilot study. Journal of gastroenterology and hepatology. 2015;30(2):268-78.
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Mehrabadi S. Interaction between Gut Microbiota Dysbiosis and Multiple Sclerosis. Int J Med Invest. 2019; 8 (3) :21-28
URL: http://intjmi.com/article-1-427-en.html

Volume 8, Issue 3 (9-2019) Back to browse issues page
International Journal of Medical Investigation
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