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:: Volume 11, Issue 4 (12-2022) ::
Int J Med Invest 2022, 11(4): 44-48 Back to browse issues page
The Role Estrogen In Schizophrenia: A Review Of Current Literature
Pooya Jafari Doudaran , Soroush Ghodratizadeh , Mitra Joudi *
Assistant Professor,Department Of Psychiatry,Golestan Research Center Of Psychiatry (Grcp),Golestan University Of Medical Sciences,Gorgan,Iran
Abstract:   (1166 Views)
Schizophrenia, a chronic and complex neuropsychiatric disorder, has a profound impact on the quality of life, social environment and health care system of patients and their families, affecting more than 21 million people worldwide. Research over the past two decades has established a distinct neuromodulatory role for estrogen in the pathogenesis and treatment of neuropsychiatric disorders, including schizophrenia. Schizophrenia is associated with an earlier age of onset, more severe disease course, poorer response to antipsychotic treatment, and disease adaptability in males with schizophrenia compared with females with schizophrenia. This neuropsychiatric disorder exhibits robust gender differences in many aspects of the disease. This review highlights the research invested in understanding the potential protective effects of estradiol in relation to these sex differences in schizophrenia. Molecular studies that have clearly demonstrated complex interactions with transmitter systems, particularly those involved in schizophrenia, have led to improvements in cognition and memory, or deficits that reflect positive, negative, and cognitive symptoms of schizophrenia.
 
Keywords: Estrogen, Schizophrenia, Review
Full-Text [PDF 533 kb]   (734 Downloads)    
Type of Study: Review | Subject: General
References
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Doudaran P J, Ghodratizadeh S, Joudi M. The Role Estrogen In Schizophrenia: A Review Of Current Literature. Int J Med Invest 2022; 11 (4) :44-48
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Volume 11, Issue 4 (12-2022) Back to browse issues page
International Journal of Medical Investigation
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