Down syndrome Associated with Epstein’s Anomaly and Pulmonary Hypertension in a 2.5 Months Infant: a Case Report Study

Tanasan, Asadollah; Rostampour, Farshad; jamei Khosroshahy, Ahmad; Sanginabadi, Milad; Falahi, Amin

[Home ] [Archive]

International Journal of Medical Investigation

Main Menu

Home

Journal Information

Articles archive

For Authors

For Reviewers

Registration

Contact us

Site Facilities

Editorial Board

Search in website

Receive site information

Volume 4, Issue 1 (march 2015)

Int J Med Invest 2015, 4(1): 187-190

Back to browse issues page

Down syndrome Associated with Epstein’s Anomaly and Pulmonary Hypertension in a 2.5 Months Infant: a Case Report Study

Asadollah Tanasan

, Farshad Rostampour ^*

, Ahmad Jamei Khosroshahy

, Milad Sanginabadi

, Amin Falahi

2. General Practitioner, Sirvan Health Network, Ilam University of Medical Sciences and Health Services, Ilam, Iran

Abstract: (11347 Views)

Abstract In children with Down syndrome (DS) there is higher chance for concomitant congenital heart defects and organic disorders. However Epstein’s anomaly is a rare association of DS. We report a 2.5 months DS boy that referred to our hospital with tachypnea. In echocardiography the septal leaflet displaced downwardly toward the apex about 8.2 mm and displacement index was 27.3 mm/m2, Tricuspid regurgitation (TR) was moderate (VC=5.5mm) with 70 mmHg gradient also an ASD with bidirectional shunt and a membranous VSD were seen. catheterisation and angiography was done, pulmonary arterial pressure was subsystemic and a 2.5 mm size PDA was seen, in the levophase a medium size VSD was seen. The patient is under follow up with lanoxin, captopril and lasix now. As mentioned earlier Epstein’s anomaly is rare and it prevalence is about 0.5% of CHDs although 50% of patients with DS have CHD but its association with Epstein’s anomaly is very rare.

Keywords: Down syndrome, Epstein anomaly, Pulmonary Hypertension, Congenital Heart Defect, Tricuspid regurgitation

Full-Text [PDF 426 kb] (2715 Downloads)

Type of Study: Research | Subject: General

References

1. 1. De Rubens Figueroa J, Del Pozza M B, Pablos HJL. Heart malformations in children with down syndrome. Rev Esp Cardiol. 2003; 56(4):894-9. 2. Tanasan A, Rostampour F, Tanasn P. Massive Pericardial Effusion in Down syndrome with Supravalvar Pulmonary Stenosis Associated to Left Pulmonary Collapse. GMJ 2014; 3(1): 61-65. 3. Ebstein W. Uber einen sehr seltenen fall von insufficienz der valvula tricuspidalis, bedingt durch eine angeborene hochgradige missbildung derselben. Arch Anat Physiol 1866; 33:238-254. 4. Epstein ML. Congenital stenosis and insufficiency of the tricuspid valve. In: Emmanuilides A, Riemens chneider G. Moss and Adams. Heart disease in infants children and Adolescents. Maryland: Williams & wilkins; 1995; 907-21. 5. Anderson KR, Zuberbuhler JR, Anderson RH, et al. Morphologic spectrum of Ebstein anomaly of the heart. Mayo Clin Proc 1979; 54:174-“180. 6. Neill CA, Zuckerberg AL. Syndromes and congenital heart defects. In: Nichols DG. Critical heart disease in infants and children. St. Louis: Mosby-year book1995; 987-1012. 7. Venturi E, Musaio L, Strazzeri R, Baroni F. Ebstein’s tricuspid anomaly and Down’s syndrome. A clinical case report. Recenti Prog Med 1992; 83: 556–558. 8. Bauk L, Espinola-Zavaleta N, Munoz-Castellanos L. Ebstein’s malformation in the setting of Down’s syndrome. Cardiol Young 2003; 13:370-2. 9. Siehr SL, Punn R, Priest JR, Lowenthal A. Ebstein anomaly and Trisomy 21: A rare association. Ann Pediatr Card 2014; 7:67-9. 10. Leite Mde F, Gianisella RB, Zielinsky P. Intrauterine detection of ebstein’s anomaly and Down’s syndrome. Prenatal diagnosis of a rare combination. Arq Bras Cardiol 2004; 82:390-5.

Add your comments about this article

Mendeley

Zotero

RefWorks

Tanasan A, Rostampour F, jamei Khosroshahy A, Sanginabadi M, Falahi A. Down syndrome Associated with Epstein’s Anomaly and Pulmonary Hypertension in a 2.5 Months Infant: a Case Report Study. Int J Med Invest 2015; 4 (1) :187-190
URL: http://intjmi.com/article-1-100-en.html

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Volume 4, Issue 1 (march 2015)

Back to browse issues page

Persian site map - English site map - Created in 0.04 seconds with 37 queries by YEKTAWEB 4660