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STUDY OF BACTERIAL AGENTS OF MENINGITIS IN CHILDREN AND DETECTION OF THEIR ANTIBIOTIC RESISTANCE PATTERNS IN HAMADAN, WESTERN IRAN
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R Yousefi Mashouf   , R Esmaeili * , A Moshtaghi |
| Student’s Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran |
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Abstract: (10821 Views) |
| Bacterial meningitis is still one of the most dangerous infection diseases and causes serious complications in children.The aim of present study was to identify the most common of bacteria causing meningitis in children under 10 years of age and detection of their resistance to antibiotics in patients who referred to hospitals of Hamadan. Overall 582 children suspected to meningitis were investigated for CSF cultures, elevation of CSF leukocyte count, hypoglucorrhachia and clinical manifestations, from January 2009 to December 2013 in two hospitals. The required data of patients were gathered through a questionnaire and analyzed using Epi6 system. The species were identified by biochemical and latex-agglutination tests. Antibiogram tests were also performed by gel-diffusion method of Kirby-Bauer. Out of 582 children suspected to meningitis, 146 children (%25.1) had positive bacterial culture that %58.9 of isolates was Gram-positive cocci and %41.1 was also Gram-negative bacilli. The most common isolates were Streptococcus (S.) pneumonia (%23.9), Staphylococcus (S.) aureus (%13.1), Escherichia (E.) coli (%10.9), Neisseria (N.) meningitides (%6.2) and Haemophilus (H.) influenzae type b (%4.1). Of 146 patients with bacterial meningitis, 79 cases (54.2%) were males and 67 cases (45.8%) were females. Fever (88.3%), Leukocytosis (74.6%), nausea and vomiting (67.1%), sleepness (66.4%) and headache (46.6%) were most common clinical manifestations of patients with bacterial meningitis. The most effective antibiotics against isolates were ceftizoxime, kanamycin, and gentamicin while most of isolates showed high resistance against ampicillin, sulfamthoxazole-trimethoprim, chloramphenicol and amoxicillin. The present study showed that gram positive cocci in particular, S. pneumoniae and S. aureus are predominant causes of bacterial meningitis in children under 10 years of age in this region. Most species showed high resistance against routine antibiotics such as amoxicillin, ampicillin and chloramphenicol. The antimicrobial susceptibility pattern for bacteria causes meningitis may provide a guideline for the selection of appropriate drug treatment. |
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Full-Text [PDF 428 kb]
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Type of Study: Research |
Subject:
General
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