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Int J Med Invest 2018, 7(4): 1-4 Back to browse issues page
Homocysteine and Folic Acid Prescription Effects on Cardiovascular Diseases
Mehri Aliasgharpour * , Fatemeh Miraliyari
Ministry of Health and Medical Education, Faculty Member of Biochemistry, Tehran, Iran
Abstract:   (53 Views)
Introduction: Homocysteine, is a sulfhydryl-containing amino acid that is typically present in very small amounts in all cells of the body.  Many investigations have indicated hyperhomocystenemia as a risk factor, which is correlated with complications such as atherosclerosis, cardiovascular disease (CVD), and stroke. The aim of the present work was to review different studies for   the lowering effect/s of folic acid supplementation on plasma homocysteine levels.
Methods: An academic search was conducted in  number of electronic databases such as EMBASE, PubMed, and etc. for the  key words; homocysteine , vitamin B12 , vitamin B6 , folic acid (vitamin B9)  and cardiovascular diseases  during years 2004 to  2018.
Findings: Review of the selected papers indicated that increased homocysteine levels as a risk marker for cardiovascular diseases, is associated with atheriosclerotic outcomes. In addition, it is considered   a higher risk of coronary artery disease in patients with chronic renal dysfunction. In apparent contrast, however, another study indicated  no risk reduction  in homocysteine-lowering trials based on prescription of folic acid and concluded that intake of high amounts of folic acid may be beneficial via the homocysteine lowering, but may also be harmful via destabilization the atherosclerotic plaque.
Conclusion: The authors conclude uncertainty of whether or not folic acid means of homocysteine lowering forms of therapy will reduce the risk of CVD remains a main focus of future research works.
Keywords: Homocysteine, Methionine, Cysteine, Atheriosclerosis, Cardiovascular Disease.
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Type of Study: Research | Subject: General
References
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Aliasgharpour M, Miraliyari F. Homocysteine and Folic Acid Prescription Effects on Cardiovascular Diseases. Int J Med Invest. 2018; 7 (4) :1-4
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Volume 7, Issue 4 (12-2018) Back to browse issues page
International Journal of Medical Investigation
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