[Home ] [Archive]    
:: Main About journal Editorial Board Current Issue Archive Submit an article Site Map Contact ::
:: Volume 9, Issue 1 (3-2020) ::
Int J Med Invest 2020, 9(1): 9-19 Back to browse issues page
Korean Red Ginseng Root Aqueous Extract with an Effective Impact on Wound Healing In Rats
Mohammad Reza Sabahi, Mehdi Nouredini, Mehrdad Taghipour, Hamid Reza Banafshe *, Seyed Mohammad Sajad Sajadian
Addiction Studies Group, Kashan University Of Medical Science, Kashan, Iran
Abstract:   (179 Views)
Introduction: There were some reports about the positive effects of some Korean red ginseng root extract ingredients on wound healing. The present study was designed to examine the effect of whole Korean red ginseng root extract ingredients on incisional wound healing and tissue tension in rats.
Methods: In this experimental study, 80 rats (Sprague Dawley, 200-250 gr) randomly divided into four groups. In day 0 a full thickness circular wound was made on the backs of these rats. They were divided into these receiver groups: Eucerin (control) and Korean red ginseng root extract (1, 10,100µg/ml) in Eucerin base were administrated daily. For tissue tension measurement 5 rats in each group were selected in days of 6, 12 and 18 after anesthesia skin incision 2 cm ×1 cm was done and tissue tensile was measured with tensiometer and data was compared by SPSS with one-way ANOVA and Tukey (P<0.05).
Findings: In this study, we had better wound healing in extract treated groups (depending on the dose) in comparison with the control group and the receiver of 100 micrograms of the extract was significantly the best.
Conclusion: Korean red ginseng root extract can be used as a medication for wound healing; probably its mechanism is increasing fibroid tissue.
Keywords: Ginseng, Wound Healing, Tissue tension, Incisional wound.
Full-Text [PDF 634 kb]   (24 Downloads)    
Type of Study: Research | Subject: General
1. 1. Baranoski S, Ayello E. Wound Care Essentials: Practice Principles. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. 2. Sussman C, Bates-Jensen B. Wound Care: A Collaborative Practice Manual for Health Professionals (Sussman, Wound Care). 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. 3. Ferguson MW, Leigh IM. Wound healing textbook of dermatolog. Blackwell Science 1998;1:337-43. 4. . Mescher, Anthony L., Luiz Carlos Uchôa Junqueira. Junqueira's Basic Histology: Text and Atlas. Thirteenth edition. New York: McGraw Hill Medical,. 2010:404-25. 5. Townsend, Courtney M., and David C. Sabiston. Sabiston Textbook of Surgery: 2001:85-91. 6. Brunicardi, F Charles; Andersen, Dana K; Billiar, Timothy R; Dunn, Schwartz's principles of surgery Tenth edition. New York : McGraw-Hill Education: 345-69 7. W.Way L. Current surgical diagnosis & treatment.Lange Ed.4. New YorkL Lange Medical Books/McGraw-Hill, 2010:458-62. 8. Ning Xu Landén, Dongqing Li, Mona Ståhle. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci 2016;73:3861-3885. 9. Sørensen LT. Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review. Ann Surg 2012;255:1069-79. 10. Sewall G, Robertson K, Connor N, Heisey D, Hartig G. Effect of topical mitomycin on skin wound contraction. Arch Facial Plast Surg 2003;5:59-62 11. Charles H. Wound assessment: measuring the area of a leg ulcer. Br J Nurs 1998;7:765e768, 770, 772. 12. Bulstrode CJ, Goode AW, Scott PJ. Stereophotogrammetry for measuring rates of cutaneous healing: a comparison with conventional techniques. Clin Sci (Lond). 1986;71:437e443 13. Cutler NR, George R, Seifert RD, Brunelle R, Sramek JJ, McNeill K, et al. Comparison of quantitative methodologies to define chronic pressure ulcer measurements. Decubitus 1993;6:22e30. 14. Etris MB, Pribble J, LaBrecque J. Evaluation of two wound measurement methods in a multi-center, controlled study. Ostomy Wound Manage 1994;40:44e48. 15. Griffin JW, Tolley EA, Tooms RE, Reyes RA, Clifft JK. A comparison of photographic and transparency-based methods for measuring wound surface area. Phys Ther 1993;73:117e122 16. Liskay AM, Mion LC, Davis BR. Comparison of two devices for wound measurement. Dermatol Nurs 1993;5:437e441, 434. 17. Bohannon RW, Pfaller BA. Documentation of wound surface area from tracings of wound perimeters. Clinical report on three techniques. Phys Ther 1983;63:1622e1624. 18. Minossi J, Lima Fde O, aramori C, Hasimoto C, rtolan E, Rodrigues P. Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats. Acta Cir Bras 2014;29:118-24 19. Ha, H., Yamamoto, M., Joo, C.N. & Kuo, S.-C. Current status of Ginseng research in Japan. In: Proceedings of the International Symposium on Ginseng Research, ROC, ed pp. 12–26. Taichuu: Life Medical Research Institute, China Medical College. 20. Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M. Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice.Br J Pharmacol 2006;148:860-70. Epub 2006 . 21. Choi,s.Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. Arch. Pharm. Res 2002;25:71-77. 22. Kenarova B, Neychev H, Hadjiivanova C, Petkov V. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 1990:447-54. 23. Sengupta, S., Toh, S.-A., Sellers, L.A., Skepper, J.N., Kollwijk, P., Leung, H.W., et al. Modulating angiogenesis The Yin and the Yang in Ginseng. Circulation 2004;110:219- 1225. 24. Shoohani B, Hemati AA, Taheri Moghadam M. Effects of Scrophularia striata Extract on Wound Healing in Rabbit. Ilam Uni Med Sci J 2009;17:9-16. 25. Rezvanipour M, Pourzadehhosseini F, Malekpour R, Zarabi A. Mummy effects on some parameters involved in wound healing in mice. Kerman University of Medical Sciences Journal 2007;14:267-77 26. Pravinkumar B, Yogita M, Kuldee B. Reversal by quercetin of corticotrophin releasing factor induced anxiety and depression like effect in rat. Prog Neuro-Psychopharmacol Biolog Psychiatry 2010;34:955-60. 27. Champion RH, Burton JL, Burns DA, Breathnach SM. Textbook of dermatology. 1998:337-9. 28. AllahTavakoli M, Arab Bani Assad F, Mahmoudi M, Jafari H, Tavakolian v, et al. Effect of Artemisia extract on cutaneous wound healing in rats. Mazandaran University of Medical Sciences 2010;20:7076 29. Heldin C-H WB. The molecular and cellular biology of wound repair. 2ed ed. : Plenum Press; 1996. 30. Madri J, Sankar S, Romanic A. The molecular and cellular biology of wound repair. 2nd ed. New York: 31. Young-Mi K, Seung N,Young-Gab Y, Hee-Do H, Young-Chul L,Kwon-Soo H, etc. Water Extract of Korean Red Ginseng Stimulates Angiogenesis by Activating the PI3K/Akt-Dependent ERK1/2 and eNOS Pathways in Human Umbilical Vein Endothelial Cells. Biol Pharm Bull 2007;30:1674-1679. 32. Jarrahi M, Vafaei AA. Effect of topical phenytoin cream on linear incisional wound healing in albino rats. DARU Journal of Pharmaceutical Sciences 2004;12:156. 33. Rezaei A, Delazar A, Mohajeri D, Taghizadeh JM, Mohammadnezhad S, Ashrafi A. Effects of Echinacea purpurea herbal extract versus zinc oxide in rat skin wound healing model, histometric and histopathologic study. Pharmaceutical Sciences 2008;1:43-52. 34. Ota T, Fujikawa-Yamamoto K, Zong Z, Yamazaki M, Odashima S, Kitagawa I. Plant-glycosidemodulation of cell surface related to control of differentiation in cultured B16 melanoma cells Cancer Res 1987;47:3863-7. 35. Mehrvarz S, Izadyar B, Nazari F. Effect of Fundermol ointment on wound healing in comparison with Normal Saline. Kowsar Medical Journal1997;2:95-100. 36. Le eJ, Jung E, Lee J, Huh S, Kim J, Park M. Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling J Ethnopharmacol 2007;109:29-34.
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sabahi M R, Nouredini M, Taghipour M, Banafshe H R, Sajadian S M S. Korean Red Ginseng Root Aqueous Extract with an Effective Impact on Wound Healing In Rats. Int J Med Invest. 2020; 9 (1) :9-19
URL: http://intjmi.com/article-1-465-en.html

Volume 9, Issue 1 (3-2020) Back to browse issues page
International Journal of Medical Investigation
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4140