[Home ] [Archive]    
:: Main About journal Editorial Board Current Issue Archive Submit an article Site Map Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 13, Issue 2 (6-2024) ::
Int J Med Invest 2024, 13(2): 9-23 Back to browse issues page
The Functional Aspects of Microbiome and Dysbiosis Alterations in Relation to Dental Implant Outcomes: A Meta-analytical Examination
Amin Rashidnezhad , Golnaz Kazemiyeh , Amin Daemi *
Department of Medical Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey
Abstract:   (282 Views)
Background: The human oral microbiome plays a crucial role in maintaining oral health, and disruptions in its equilibrium can lead to dysbiosis, contributing to various oral diseases, including peri-implantitis in dental implant patients. This study aims to explore the functionality and dysbiosis dynamics of the oral microbiome in dental implant outcomes to elucidate the microbial factors influencing peri-implant health and disease progression.
Methods: A meta-analytical approach was employed to investigate the functional aspects of microbiome and dysbiosis alterations concerning dental implant outcomes. A comprehensive literature search was conducted to identify relevant studies. Inclusion criteria were applied to select studies focusing on the relationship between the oral microbiome, dysbiosis, and dental implant outcomes. Data extraction was performed to collect relevant information from the selected studies. Statistical analysis, including effect size calculation and heterogeneity assessment, was conducted to synthesize the findings across studies. Sensitivity analysis and assessment of publication bias were performed to ensure the robustness of the results.
Results: Eight studies were analyzed, including 217 subjects in the Experimental group and 201 in the Control group. Using a random effects model with the Mantel-Haenszel method, a significant difference was found between the two groups, with an overall risk ratio of 2.26 and a 95% confidence interval of 1.13 to 4.5.
Conclusion: Significant heterogeneity was observed, indicating that the effects varied widely in magnitude and direction across studies. The I² value showed that 95% of the variability among studies was due to heterogeneity rather than random chance.
 
Keywords: Oral Microbiome, Dental Implants, Peri-Implantitis, Dysbiosis Dynamics
Full-Text [PDF 838 kb]   (36 Downloads)    
Type of Study: Review | Subject: General
References
1. Kensara., Anmar, Adnan, Hanae, Saito., Emmanuel, F., Mongodin., Radi, Masri. (2023). Microbiological profile of peri-implantitis: Analyses of microbiome within dental implants.. Journal of Prosthodontics, doi: 10.1111/jopr.13653 2. Barbagallo., Giovanni, Maria, Santagati., Alaa, Guni., Paolo, Torrisi., Ambra, Spitale., Stefania, Stefani., Sebastiano, Ferlito., Luigi, Nibali. (2021). Microbiome differences in periodontal, peri-implant, and healthy sites: a cross-sectional pilot study.. Clinical Oral Investigations, 1-11. doi: 10.1007/S00784-021-04253-4 3. Belibasakis., Georgios, N., Daniel, Manoil. (2021). Microbial Community- Driven Etiopathogenesis of Peri-Implantitis:. Journal of Dental Research, 100(1):21-28. doi: 10.1177/0022034520949851 4. Alves., Carlos, Henrique, Karolayne, Larissa, Russi., Natália, Conceição, Rocha., Fábio, Bastos., Michelle, Darrieux., Thaís, Manzano, Parisotto., Raquel, Girardello. (2022). Host-microbiome interactions regarding peri- implantitis and dental implant loss. Journal of Translational Medicine, 20(1) doi: 10.1186/s12967-022-03636-9 5. Kumar. Purnima, S., (2022). Biome‐microbiome interactions in peri‐ implantitis: A pilot investigation. Journal of Periodontology, 93(6):814-823. doi: 10.1002/jper.21-0423 6. Ganesan., Sukirth, M., Shareef, M., Dabdoub., Haikady, N., Nagaraja., Angelo, Mariotti., Christopher, William, Ludden., Purnima, S., Kumar. (2022). Biome-microbiome interactions in peri-implantitis: a pilot investigation.. The Journal of periodontology, doi: 10.1002/JPER.21-0423 7. Gazil., Virginie, Octave, Nadile, Bandiaky., Emmanuelle, Renard., Katia, Idiri., Xavier, Struillou., Assem, Soueidan. (2022). Current Data on Oral Peri- Implant and Periodontal Microbiota and Its Pathological Changes: A Systematic Review. Microorganisms, 10(12):2466-2466. doi: 10.3390/microorganisms10122466 8. Rodriguez-Archilla., Alberto, Barbara, Palma-Casiano. (2022). Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis. Journal of Inflammatory Diseases, 25(4):241-250. doi: 10.32598/jid.25.4.1 9. Raza., Fathima, Banu, Sivakumar, Vijayaragavalu., Ruckmani, Kandasamy., Venkateshwaran, Krishnaswami., Anand, Kumar. (2022). Microbiome and the inflammatory pathway in peri-implant health and disease with an updated review on treatment strategies. Journal of oral biology and craniofacial research, 13(2):84-91. doi: 10.1016/j.jobcr.2022.11.005 10. D’Ambrosio., Francesco, Biagio, Santella., Mariagiovanna, Di, Palo., F, Giordano., Roberto, Lo, Giudice. (2023). Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant- Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review. Microorganisms, 11(4):1041-1041. doi: 10.3390/microorganisms11041041. 11. Amato., Massimo, Federica, di, Spirito., Francesco, D’Ambrosio., Giovanni, Boccia., Giuseppina, Moccia., Francesco, De, Caro. (2022). Probiotics in Periodontal and Peri-Implant Health Management: Biofilm Control, Dysbiosis Reversal, and Host Modulation. Microorganisms, 10(11):2289- 2289. doi: 10.3390/microorganisms10112289 12. Tsitsiashvili., A., M., A., M., Panin., Ye.N., Nikolayeva., A.A., Arutyunyan., M., S., Podporin., V.N., Tsarev. (2019). Microbial contamination dynamics in surgical treatment of patients using dental implants in a limited bone tissue volume. 52-58. doi: 10.35556/IDR-2019-4(89)52-58 13. Bogacheva. N., A., (2022). Diagnostically significant cultured anaerobic microorgan-isms in the development of periimplantites. Эпидемиология и инфекционные болезни, 26(4):174-186. doi: 10.17816/eid108467 14. Vernon., J., J., El, Mostafa, Raïf., Jensen, Aw., Edward, Attenborough., Animesh, Jha., Thuy, Do. (2022). Dental implant surfaces and their interaction with the oral microbiome. Dentistry review, 2(4):100060-100060. doi: 10.1016/j.dentre.2022.100060 15. Pan., Piaopiao, Yichao, Gu., Donglei, Sun., Qinglong, L., Wu., Ning, Zhou. (2023). Microbial Diversity Biased Estimation Caused by Intragenomic Heterogeneity and Interspecific Conservation of 16S rRNA Genes. Applied and Environmental Microbiology, 89(5) doi: 10.1128/aem.02108-22 16. Onen., O., I., A., A., Aboh., A., N., Mfam., M., O., Akor., C., N., Nweke., A., N., Osuagwu. (2020). Microbial Diversity: Values and Roles in Ecosystems. 10-22. doi: 10.9734/AJOB/2020/V9I130075 17. Liu., L., Z., Xi, Chen., Gangxiong, Jin., Minhong, Cai., Zhuoya, Qiu. (2022). Microbial diversity in marine sediments of two hydrocarbon reservoir areas in the eastern Atlantic Ocean. Aquatic Microbial Ecology, 88:109-122. doi: 10.3354/ame01987 18. Astrid, Catalina, Alvarez-Yela., Jeanneth, Mosquera-Rendón., Alejandra, Noreña-P., Marco, Cristancho., Diana, López-Alvarez. (2019). Microbial Diversity Exploration of Marine Hosts at Serrana Bank, a Coral Atoll of the Seaflower Biosphere Reserve. Frontiers in Marine Science, 6 doi: 10.3389/FMARS.2019.00338 19. Daubert., Diane, M., Bradley, F., Weinstein. (2019). Biofilm as a risk factor in implant treatment.. Periodontology 2000, 81(1):29-40. doi: 10.1111/PRD.12280 20. Hamze., Malak, Saad, Fadhel. (2017). Microbial Composition in Peri-implant Health and Disease. 21. Tsigarida., Alexandra, Shareef, M., Dabdoub., Haikady, N., Nagaraja., Purnima, S., Kumar. (2015). The Influence of Smoking on the Peri-Implant Microbiome. Journal of Dental Research, 94(9):1202-1217. doi: 10.1177/0022034515590581 22. Zheng, H., Xu, L., Wang, Z. et al. Subgingival microbiome in patients with healthy and ailing dental implants. Sci Rep 5, 10948 (2015). https://doi.org/10.1038/srep10948 23. Pallos, D., Sousa, V., Feres, M., Retamal-Valdes, B., Chen, T., Curtis, M., ... & Shibli, J. A. (2022). Salivary microbial dysbiosis is associated with peri- implantitis: a case-control study in a Brazilian population. Frontiers in Cellular and Infection Microbiology, 11, 696432. 24. Korsch, M., Marten, SM., Stoll, D. et al. Microbiological findings in early and late implant loss: an observational clinical case-controlled study. BMC Oral Health 21, 112 (2021). https://doi.org/10.1186/s12903-021-01439-w. 25. Zhang Y, Li Y, Yang Y, Wang Y, Cao X, Jin Y, Xu Y, Li SC and Zhou Q (2022) Periodontal and Peri-Implant Microbiome Dysbiosis Is Associated With Alterations in the Microbial Community Structure and Local Stability. Front. Microbiol. 12:785191. doi: 10.3389/fmicb.2021.785191 26. Manzoor, M., Leskelä, J., Pietiäinen, M., Martinez-Majander, N., Könönen, E., Niiranen, T., ... & Paju, S. (2024). Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study. Journal of Oral Microbiology, 16(1), 2330867. 27. Sun, F., Wei, Y., Li, S., Nie, Y., Wang, C., & Hu, W. (2023). Shift in the submucosal microbiome of diseased peri-implant sites after non-surgical mechanical debridement treatment. Frontiers in Cellular and Infection Microbiology, 12, 1091938. 28. Menini, M., Delucchi, F., Bagnasco, F., Pera, F., Di Tullio, N., & Pesce, P. (2020). Analysis of the subgingival microbiota in implant-supported full-arch rehabilitations. Dentistry Journal, 8(3), 104. 29. Inchingolo., Alessio, Danilo, G, Malcangi., A., B., Semjonova., Angelo, M, Inchingolo., Assunta, Patano., G., Coloccia., Sabino, Ceci., G., Marinelli., Chiara, Di, Pede., Annamaria, Ciocia., Antonio, Mancini., Giulia, Palmieri., Giuseppe, Barile., Vito, Settanni., Nicole, De, Leonardis., Biagio, Rapone., Fabio, Piras., Fabio, Viapiano., F., Cardarelli., Ludovica, Nucci., Ioana, Roxana, Bordea., Antonio, Scarano., Felice, Lorusso., Andrea, Palermo., Stefania, Costa., Gianluca, M., Tartaglia., Alberto, Corriero., Nicola, Brienza., Daniela, Di, Venere., Francesco, Inchingolo., Gianna, Dipalma. (2022). Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature. Children (Basel), 9(7):1014-1014. doi: 10.3390/children9071014 30. Rodriguez-Archilla., Alberto, Barbara, Palma-Casiano. (2022). Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis. Journal of Inflammatory Diseases, 25(4):241-250. doi: 10.32598/jid.25.4.1 31. D’Ambrosio., Francesco, Biagio, Santella., Mariagiovanna, Di, Palo., F, Giordano., Roberto, Lo, Giudice. (2023). Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant- Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review. Microorganisms, 11(4):1041-1041. doi: 10.3390/microorganisms11041041 32. Muzio., Eleonora, Lo, Henk, ten, Have. (2023). Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic Inflammation with Special Reference to Periodontitis: Current Knowledge and Perspectives. Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 23(4):470-484. doi: 10.2174/1871530322666220629101357 33. Dono, Kahharova., Vincent, Y., Pappalardo., Mark, J., Buijs., Richard, Jackson., Anderson, T., Hara., George, Eckert., B., Katz., Martha, Ann, Keels., Steven, M., Levy., Egija, Zaura., Bernd, W., Brandt., Margherita, Fontana. (2023). Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries. Journal of Dental Research, 102(7):759-766. doi: 10.1177/00220345231160756 34. Siddiqui., Ruqaiyyah, Zahi, Badran., Anania, Boghossian., Ahmad, M., Alharbi., Hasan, Alfahemi., Naveed, Ahmed, Khan. (2023). The increasing importance of the oral microbiome in periodontal health and disease. Future Science OA, doi: 10.2144/fsoa-2023-0062 35. Robertson. Patricia, (2022). Implantogenomic: Conceptualizing Osseointegration Toward Personalized Dental Implant Therapy. doi: 10.5772/intechopen.109159 36. Hernandez. Marcela, Marcia, Pinto, Alves, Mayer., Julien, Santi-Rocca. (2022). Editorial: The Human Microbiota in Periodontitis. Frontiers in Cellular and Infection Microbiology, 12 doi: 10.3389/fcimb.2022.952205 37. Chenfeng, Chen., Shuaiqi, Gan., Yihan, Liao., Rui-Jia, Fu., Chuping, Hou., Zheng, Zheng., Wenchuan, C., Chen. (2023). The Potential Value of Probiotics after Dental Implant Placement. Microorganisms, doi: 10.3390/m Mara, A., Serbanescu., Camille, G., Apple., Joseph, S., Fernandez-Moure. (2023). Role of Resident Microbial Communities in Biofilm-Related Implant Infections: Recent Insights and Implications.. Surgical Infections, 24 3(3):258-264. doi: 10.1089/sur.2023.009 icroorganisms11071845 38. Drago., Lorenzo, Carlo, Luca, Romanò. (2022). Commentary: Challenges in the Microbiological Diagnosis of Implant-Associated Infections: A Summary of the Current Knowledge. Frontiers in Microbiology, 12 doi: 10.3389/fmicb.2021.814945 39. Zhang., Yuchen, Sadia, Niazi., Yuguang, Yang., Yi-Qing, Wang., Xiao-Xiao, Cao., Yibing, Liu., Yinhu, Li., Qin, Zhou. (2022). Smoking by altering the peri-implant microbial community structure compromises the responsiveness to treatment. Frontiers in Cellular and Infection Microbiology, 12 doi: 10.3389/fcimb.2022.1040765. 40. Arjono., Melina, Kirchartz. (2022). Periodontal and Peri-Implant Microbiome Dysbiosis Is Associated With Alterations in the Microbial Community Structure and Local Stability. Frontiers in Microbiology, 12 doi: 10.3389/fmicb.2021.785191 41. Nikhil, Sethi., Swarna, Meenakshi, S., Thiyaneshwaran, Nesappan., Rajesh, Kumar. (2023). Bridging the Gap with Nanoparticles: A Novel Approach.. Journal of Long-term Effects of Medical Implants, 33 2(2):15-22. doi: 10.1615/jlongtermeffmedimplants.2022041755 42. Pei-Shiuan, Yu, Pei-Shiuan, Yu., Pei-Shiuan, Yu. (2022). The Microbiome of Peri-implantitis Using Next-Generation Sequencing with 16S rRNA Gene: A Systematic Review. Journal of Periodontics and Implant Dentistry, 5(2):094- 106. doi: 10.53106/261634032022090502003 43. Kensara, A., Saito, H., Mongodin, E. F., & Masri, R. (2023). Microbiological profile of peri‐implantitis: Analyses of peri‐implant microbiome. Journal of Prosthodontics. 44. Safarov., M, T, K, M, Tashpulatova. (2020). Aspects of Microflora Disturbance in the Implant-gingival Sulcus in Patients Using Fixed Bridges with Support on Dental Implants. American Journal of Medicine and Medical Sciences.
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rashidnezhad A, Kazemiyeh G, Daemi A. The Functional Aspects of Microbiome and Dysbiosis Alterations in Relation to Dental Implant Outcomes: A Meta-analytical Examination. Int J Med Invest 2024; 13 (2) :9-23
URL: http://intjmi.com/article-1-1157-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 2 (6-2024) Back to browse issues page
International Journal of Medical Investigation
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4660